Miao Su-Yu, Zhou Wenbin, Chen Ling, Wang Shui, Liu Xiao-An
Department of Breast Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Asia Pac J Clin Oncol. 2014 Jun;10(2):101-8. doi: 10.1111/ajco.12083. Epub 2013 May 29.
Blood group is an important risk factor for some malignancies, including pancreatic and stomach cancer. However, it is unclear whether the risk of breast cancer is higher in any specific ABO blood type.
We searched the electronic database of PubMed, EMBASE, China National Knowledge Infrastructure and the VIP Chinese Journal of Science and Technology for case-control studies about blood type and breast cancer incidence, and a meta-analysis was conducted.
Fourteen studies were eligible for assessment on the association of breast cancer with different blood types, including 9665 breast cancer patients and 244,768 controls. Relative to blood type O, women with blood type A (odds ratio (OR) = 1.115, 95% confidence interval (CI) 0.992-1.254), B (OR = 0.983, 95% CI 0.915-1.056) and AB (OR = 1.042, 95% CI 0.881-1.231) had the same breast cancer risk. The risk for women with Rhesus-positive (Rh+) was the same as those with Rh-negative (Rh-) (OR = 0.948, 95% CI 0.667-1.348). Among Caucasians, the OR of blood type A was 1.066 (95% CI, 1.001-1.134, P = 0.522 for heterogeneity).
This meta-analysis suggests Caucasians with blood type A may have a higher risk of breast cancer than other Caucasians. No association was found in any other blood type or any other population. Similarly, the Rh factor had no association with the risk of breast cancer.
血型是包括胰腺癌和胃癌在内的某些恶性肿瘤的重要危险因素。然而，尚不清楚在任何特定的ABO血型中乳腺癌风险是否更高。
我们检索了PubMed、EMBASE、中国知网和维普中文科技期刊数据库中关于血型与乳腺癌发病率的病例对照研究，并进行了荟萃分析。
14项研究符合评估乳腺癌与不同血型关联的条件，包括9665例乳腺癌患者和244,768例对照。相对于O型血，A型血（比值比（OR）=1.115，95%置信区间（CI）0.992 - 1.254）、B型血（OR = 0.983，95% CI 0.915 - 1.056）和AB型血（OR = 1.042，95% CI 0.881 - 1.231）的女性患乳腺癌风险相同。恒河猴阳性（Rh+）女性的风险与恒河猴阴性（Rh-）女性相同（OR = 0.948，95% CI 0.667 - 1.348）。在白种人中，A型血的OR为1.066（95% CI，1.001 - 1.134，异质性P = 0.522）。
这项荟萃分析表明，A型血的白种人患乳腺癌的风险可能高于其他白种人。在任何其他血型或任何其他人群中均未发现关联。同样，Rh因子与乳腺癌风险无关。
