ABO血型与癌症风险——一项对台湾339432名受试者的队列研究。
ABO blood types and cancer risk--a cohort study of 339,432 subjects in Taiwan.
作者信息
Sun Wenjie, Wen Chi-Pang, Lin Jie, Wen Christopher, Pu Xia, Huang Maosheng, Tsai Min Kuang, Tsao Chwen Keng, Wu Xifeng, Chow Wong-Ho
机构信息
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Institute of Population Health Science, National Health Research Institutes, Zhunan, Taiwan; China Medical University Hospital, Taichung, Taiwan.
出版信息
Cancer Epidemiol. 2015 Apr;39(2):150-6. doi: 10.1016/j.canep.2014.12.006. Epub 2015 Jan 16.
BACKGROUND
The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined.
METHODS
The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort.
RESULTS
Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O.
CONCLUSION
Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
背景
基于实验室检测的ABO血型与癌症风险及死亡率之间的关联尚未得到系统确定。
方法
研究对象为来自台湾队列的339432名有实验室检测血型的健康个体。
结果
与O型血相比，在调整年龄、性别、教育程度、吸烟、饮酒、身体活动和体重指数后，A型血与胃癌发病风险升高（风险比[HR]，1.38[95%置信区间，1.11 - 1.72]）及死亡率升高（HR，1.38[95%置信区间，1.02 - 1.86]）显著相关。非O型血与胰腺癌风险升高相关，B型血在发病率（HR，1.59[95%置信区间，1.02 - 2.48]）及死亡率（HR，1.63[95%置信区间，1.02 - 2.60]）方面达到统计学显著水平。相比之下，与O型血相比，AB型血与肾癌风险呈负相关（HR，0.41[95%置信区间，0.18 - 0.93]）。
结论
不同ABO血型人群的癌症风险各不相同，A型血与胃癌风险升高相关，非O型血（A、B和AB型）与胰腺癌风险升高相关。
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