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肺癌患者肝脏转移破裂的诊断困境:病例报告。

The Diagnostic Dilemma of Ruptured Liver Metastasis in a Patient with Lung Cancer: A case report.

机构信息

Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

出版信息

Sultan Qaboos Univ Med J. 2022 Aug;22(3):421-425. doi: 10.18295/squmj.6.2021.091. Epub 2022 Aug 25.

DOI:10.18295/squmj.6.2021.091
PMID:36072072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9423753/
Abstract

Spontaneous rupture of a metastatic liver tumour is rarely documented in the literature when compared to hepatocellular carcinoma and other liver lesions, especially from a lung primary. We report a case of ruptured liver metastasis from an adenocarcinoma of the lung mimicking ruptured liver abscess, challenging the clinical diagnosis. A 42-year-female patient presented to a tertiary care institute in 2020 with complaints of abdominal pain, breathlessness and fever. On examination, the patient was tachypnoeic with a right hypochondriac mass. A contrast-enhanced computed tomography of abdomen and thorax revealed an ill-defined heterogeneously enhancing lesion in the liver with a communicating subcapsular collection and hypo-enhancing lesions in the left lobe and heterogeneously enhancing lesion in the left lung. Adenocarcinoma of the lung with hepatic metastasis was confirmed with a core needle biopsy. The patient was managed conservatively with intravenous antibiotics, intercostal drainage tube and gefitinib. However, despite best efforts, the patient succumbed to the disease.

摘要

与肝细胞癌和其他肝脏病变相比,转移性肝脏肿瘤的自发性破裂在文献中很少被记录,尤其是来自肺部原发性肿瘤的情况。我们报告了一例来自肺腺癌的破裂肝转移病例,其表现类似于破裂性肝脓肿,对临床诊断构成了挑战。一名 42 岁女性患者于 2020 年因腹痛、呼吸困难和发热就诊于一家三级保健机构。体格检查时,患者呼吸急促,右季肋部有肿块。腹部和胸部的增强 CT 显示肝脏内有一个边界不清的不均匀增强病变,伴有一个囊下连通性积液,左叶有低增强病变,左肺有不均匀增强病变。肺腺癌伴肝转移经芯针活检证实。患者接受了静脉内抗生素、肋间引流管和吉非替尼的保守治疗。然而,尽管尽了最大努力,患者还是死于该疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/151a1eeac08f/squmj2208-421-425f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/52084a43a3ab/squmj2208-421-425f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/97cb9d791c40/squmj2208-421-425f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/151a1eeac08f/squmj2208-421-425f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/52084a43a3ab/squmj2208-421-425f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/97cb9d791c40/squmj2208-421-425f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0d/9423753/151a1eeac08f/squmj2208-421-425f3.jpg

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本文引用的文献

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An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review.小细胞肺癌肝转移破裂的尸检病例:一例报告及文献复习
Respir Med Case Rep. 2020 Mar 19;30:101039. doi: 10.1016/j.rmcr.2020.101039. eCollection 2020.
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mMRC dyspnoea scale indicates impaired quality of life and increased pain in patients with idiopathic pulmonary fibrosis.
改良英国医学研究委员会呼吸困难量表表明,特发性肺纤维化患者的生活质量受损且疼痛加剧。
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Hemoperitoneum Secondary to Rupture of a Hepatic Metastasis from Small Cell Lung Cancer during Chemotherapy: A Case with a Literature Review.化疗期间小细胞肺癌肝转移瘤破裂继发腹腔积血:1例病例报告并文献复习
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Metastatic sites and survival in lung cancer.肺癌的转移部位与生存情况
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