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度普利尤单抗相关的嗜酸性肉芽肿性多血管炎

Dupilumab-Associated Eosinophilic Granulomatosis With Polyangiitis.

作者信息

Persaud Purnadeo, Karmali Rehan, Sankar Parvathy, Majid Muhammad

机构信息

Internal Medicine, Cleveland Clinic, Cleveland, USA.

Cardiology, Cleveland Clinic, Cleveland, USA.

出版信息

Cureus. 2022 Aug 4;14(8):e27670. doi: 10.7759/cureus.27670. eCollection 2022 Aug.

DOI:10.7759/cureus.27670
PMID:36072184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9440334/
Abstract

A 58-year-old Caucasian male developed generalized weakness, bilateral upper and lower extremity arthralgias, left pedal edema, and a new rash over two weeks after receiving one dose of dupilumab for chronic sinusitis. He was found to be positive for perinuclear anti-neutrophil cytoplasmic antibodies and myeloperoxidase, with evidence of interstitial lung disease on CT imaging. A skin biopsy showed eosinophilic vasculitis and a kidney biopsy showed pauci-immune glomerulonephritis. He was diagnosed with eosinophilic granulomatosis with polyangiitis due to dupilumab exposure.

摘要

一名58岁的白种男性在接受一剂度普利尤单抗治疗慢性鼻窦炎两周后，出现全身无力、双侧上下肢关节痛、左足水肿及新发皮疹。发现其核周抗中性粒细胞胞浆抗体和髓过氧化物酶呈阳性，CT成像显示有间质性肺病的证据。皮肤活检显示嗜酸性血管炎，肾脏活检显示寡免疫性肾小球肾炎。他被诊断为因接触度普利尤单抗导致的嗜酸性肉芽肿性多血管炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/d19c355a4494/cureus-0014-00000027670-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/689428ee95d7/cureus-0014-00000027670-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/ff7ff2800bc0/cureus-0014-00000027670-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/8b71b38707c0/cureus-0014-00000027670-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/d19c355a4494/cureus-0014-00000027670-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/689428ee95d7/cureus-0014-00000027670-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/ff7ff2800bc0/cureus-0014-00000027670-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/8b71b38707c0/cureus-0014-00000027670-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ed/9440334/d19c355a4494/cureus-0014-00000027670-i04.jpg

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J Allergy Clin Immunol Pract. 2022 Oct;10(10):2695-2709. doi: 10.1016/j.jaip.2022.05.019. Epub 2022 May 28.
2
Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab.重度哮喘患者在停用度普利尤单抗后出现嗜酸性肉芽肿性多血管炎。
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3
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J Allergy Clin Immunol. 2025 May;155(5):1584-1594. doi: 10.1016/j.jaci.2024.10.028. Epub 2024 Nov 7.
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