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不孕的原因:微流控精子分选仪的诊断与管理

Causes of Infertility: Diagnosis and Management With Microfluidic Sperm Sorter.

作者信息

Chauhan Saurabh, More Akash, Shrivastava Deepti, Gajbe Ujwal

机构信息

Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Medical Sciences, Wardha, IND.

Senior Embryologist, Datta Meghe Institute of Medical Sciences, Wardha, IND.

出版信息

Cureus. 2022 Aug 4;14(8):e27674. doi: 10.7759/cureus.27674. eCollection 2022 Aug.

Abstract

This case study refers to a three-and-a-half-year married couple who visited an infertility clinic and are facing infertility for two-and-a-half years. They started in vitro fertilization/assisted reproduction technology (IVF/ART) procedures from December 2021. In 2019, the couple underwent infertility therapy in Wardha, India, including three intra-uterine insemination (IUI) treatments which failed. The couple was then recommended the intracytoplasmic sperm injection (ICSI) procedure in which the semen sample was separated using a microfluidic sperm sorter for separating good quality sperms. There was no past medical history of both of the partners. Since she was infertile, the desire to have a child was extremely strong. Sadness, helplessness, bewilderment, and frustration are all common feelings associated with infertility. The left fallopian tube delays spillage in females and oligoasthenozoospermia in males; women were detected with secondary infertility and male sperm samples were sorted using a microfluidic sperm sorter and fertilized frozen oocytes for ICSI. As the male partner, in this case, had oligoasthenozoospermia, he was prescribed multivitamins and other medications. After ICSI, the blastocyst formation was good with the use of a microfluidic sperm sorter.

摘要

本案例研究涉及一对结婚三年半的夫妇,他们前往一家不孕不育诊所,面临两年半的不孕问题。他们从2021年12月开始接受体外受精/辅助生殖技术(IVF/ART)治疗。2019年,这对夫妇在印度瓦尔达接受了不孕治疗,包括三次宫腔内人工授精(IUI)治疗,但均失败。随后,这对夫妇被建议进行卵胞浆内单精子注射(ICSI)手术,其中精液样本使用微流控精子分选仪进行分离,以分离出高质量的精子。夫妻双方均无既往病史。由于她不孕,想要孩子的愿望极其强烈。悲伤、无助、困惑和沮丧都是与不孕相关的常见情绪。女性左侧输卵管造影剂延迟溢出,男性少弱精子症;检测到女性继发性不孕,男性精子样本使用微流控精子分选仪进行分选,并对冷冻卵母细胞进行受精用于ICSI。在本案例中,由于男性伴侣患有少弱精子症,给他开了多种维生素和其他药物。ICSI后,使用微流控精子分选仪,囊胚形成良好。

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Anxiety, Difficulties, and Coping of Infertile Women.不孕女性的焦虑、困难与应对
Healthcare (Basel). 2021 Apr 15;9(4):466. doi: 10.3390/healthcare9040466.
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Associated factors with male infertility: a case control study.男性不育的相关因素:一项病例对照研究。
J Clin Diagn Res. 2014 Sep;8(9):FC11-3. doi: 10.7860/JCDR/2014/8611.4887. Epub 2014 Sep 20.

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