Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, United States.
Front Cell Infect Microbiol. 2022 Aug 22;12:958555. doi: 10.3389/fcimb.2022.958555. eCollection 2022.
Treatment of ( infections is particularly arduous. One challenge to effectively treating tuberculosis is that drug efficacy often fails to match drug efficacy This is due to multiple reasons, including inadequate drug concentrations reaching at the site of infection and physiological changes of in response to host derived stresses that render the bacteria more tolerant to antibiotics. To more effectively and efficiently treat tuberculosis, it is necessary to better understand the physiologic state of that promotes drug tolerance in the host. Towards this end, multiple studies have converged on bacterial central carbon metabolism as a critical contributor to drug tolerance. In this review, we present the evidence that changes in central carbon metabolism can promote drug tolerance, depending on the environment surrounding . We posit that these metabolic pathways could be potential drug targets to stymie the development of drug tolerance and enhance the efficacy of current antimicrobial therapy.
（感染的）治疗特别艰难。有效治疗结核病的一个挑战是，药物疗效往往无法与药物效力相匹配。这是由于多种原因造成的，包括到达感染部位的药物浓度不足，以及细菌对宿主来源的应激的生理变化，使细菌对抗生素更具耐受性。为了更有效地治疗结核病，有必要更好地了解促进宿主中药物耐受性的细菌生理状态。为此，多项研究都集中在细菌的中心碳代谢上，认为这是导致细菌药物耐受性的关键因素。在这篇综述中，我们提出了证据，表明中心碳代谢的变化可以根据周围环境促进药物耐受性。我们假设这些代谢途径可能是潜在的药物靶点，可以阻止药物耐受性的发展，提高现有抗菌治疗的疗效。
