Danchik Carina, Wang Siqing, Karakousis Petros C
Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Front Microbiol. 2021 Oct 7;12:744167. doi: 10.3389/fmicb.2021.744167. eCollection 2021.
The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria. It is mediated by the alarmone (p)ppGpp and the regulatory molecule inorganic polyphosphate in response to stress conditions such as nutrient starvation. Efforts to pharmacologically target various components of the stringent response have shown promise in modulating mycobacterial virulence and antibiotic tolerance. In this review, we summarize the current understanding of the stringent response and its role in virulence and tolerance in Mycobacteria, including evidence that targeting this pathway could have therapeutic benefit.
严谨反应在细菌物种中高度保守，是一条关键途径，既参与细菌的生存和毒力，也参与分枝杆菌中抗生素耐受性的诱导。它由警报素（p）ppGpp和调节分子无机多聚磷酸盐介导，以应对营养饥饿等应激条件。针对严谨反应的各种组分进行药理学靶向的研究已显示出在调节分枝杆菌毒力和抗生素耐受性方面的前景。在本综述中，我们总结了目前对严谨反应及其在分枝杆菌毒力和耐受性中的作用的理解，包括靶向该途径可能具有治疗益处的证据。
