Liu Si-Qing, Li Bei, Li Juan-Juan, Sun Si, Sun Sheng-Rong, Wu Qi
Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Front Cell Dev Biol. 2022 Aug 22;10:896147. doi: 10.3389/fcell.2022.896147. eCollection 2022.
Immune responses in nonlymphoid tissues play a vital role in the maintenance of homeostasis. Lots of evidence supports that tissue-specific immune cells provide defense against tumor through the localization in different tissue throughout the body, and can be regulated by diverse factors. Accordingly, the distribution of nervous tissue is also tissue-specific which is essential in the growth of corresponding organs, and the occurrence and development of tumor. Although there have been many mature perspectives on the neuroendocrine regulation in tumor microenvironment, the neuroendocrine regulation of tissue-specific immune cells has not yet been summarized. In this review, we focus on how tissue immune responses are influenced by autonomic nervous system, sensory nerves, and various neuroendocrine factors and reversely how tissue-specific immune cells communicate with neuroendocrine system through releasing different factors. Furthermore, we pay attention to the potential mechanisms of neuroendocrine-tissue specific immunity axis involved in tumors. This may provide new insights for the immunotherapy of tumors in the future.
非淋巴组织中的免疫反应在维持体内平衡中起着至关重要的作用。大量证据表明，组织特异性免疫细胞通过在全身不同组织中的定位为肿瘤提供防御，并且可受多种因素调节。相应地，神经组织的分布也是组织特异性的，这对于相应器官的生长以及肿瘤的发生和发展至关重要。尽管关于肿瘤微环境中的神经内分泌调节已经有许多成熟的观点，但组织特异性免疫细胞的神经内分泌调节尚未得到总结。在本综述中，我们关注自主神经系统、感觉神经和各种神经内分泌因子如何影响组织免疫反应，以及组织特异性免疫细胞如何通过释放不同因子与神经内分泌系统进行反向沟通。此外，我们关注神经内分泌 - 组织特异性免疫轴参与肿瘤的潜在机制。这可能为未来肿瘤的免疫治疗提供新的见解。
