Zuroff Leah, Wisse Laura Em, Glenn Trevor, Xie Sharon X, Nasrallah Ilya M, Habes Mohamad, Dubroff Jacob, de Flores Robin, Xie Long, Yushkevich Paul, Doshi Jimit, Davatsikos Christos, Shaw Leslie M, Tropea Thomas F, Chen-Plotkin Alice S, Wolk David A, Das Sandhitsu, Mechanic-Hamilton Dawn
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Diagnostic Radiology, Lund University, Lund, Sweden.
J Alzheimers Dis Rep. 2022 Jul 22;6(1):411-430. doi: 10.3233/ADR-220013. eCollection 2022.
Episodic memory decline is a hallmark of Alzheimer's disease (AD). Subjective memory complaints (SMCs) may represent one of the earliest signs of impending cognitive decline. The degree to which self- or partner-reported SMCs predict cognitive change remains unclear.
We aimed to evaluate the relationship between self- and partner-reported SMCs, objective cognitive performance, AD biomarkers, and risk of future decline in a well-characterized longitudinal memory center cohort. We also evaluated whether study partner characteristics influence reports of SMCs.
758 participants and 690 study partners were recruited from the Penn Alzheimer's Disease Research Center Clinical Core. Participants included those with Normal Cognition, Mild Cognitive Impairment, and AD. SMCs were measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), and were evaluated for their association with cognition, genetic, plasma, and neuroimaging biomarkers of AD, cognitive and functional decline, and diagnostic progression over an average of four years.
We found that partner-reported SMCs were more consistent with cognitive test performance and increasing symptom severity than self-reported SMCs. Partner-reported SMCs showed stronger correlations with AD-associated brain atrophy, plasma biomarkers of neurodegeneration, and longitudinal cognitive and functional decline. A 10-point increase on baseline PRMQ increased the annual risk of diagnostic progression by approximately 70%. Study partner demographics and relationship to participants influenced reports of SMCs in AD participants only.
Partner-reported SMCs, using the PRMQ, have a stronger relationship with the neuroanatomic and cognitive changes associated with AD than patient-reported SMCs. Further work is needed to evaluate whether SMCs could be used to screen for future decline.
情景记忆衰退是阿尔茨海默病（AD）的一个标志。主观记忆抱怨（SMCs）可能是即将发生认知衰退的最早迹象之一。自我报告或伴侣报告的SMCs预测认知变化的程度尚不清楚。
我们旨在评估在一个特征明确的纵向记忆中心队列中，自我报告和伴侣报告的SMCs、客观认知表现、AD生物标志物以及未来衰退风险之间的关系。我们还评估了研究伴侣的特征是否会影响SMCs的报告。
从宾夕法尼亚阿尔茨海默病研究中心临床核心招募了758名参与者和690名研究伴侣。参与者包括认知正常、轻度认知障碍和AD患者。使用前瞻性和回顾性记忆问卷（PRMQ）测量SMCs，并评估其与AD的认知、遗传、血浆和神经影像学生物标志物、认知和功能衰退以及平均四年内诊断进展的关联。
我们发现，与自我报告的SMCs相比，伴侣报告的SMCs与认知测试表现和症状严重程度增加更一致。伴侣报告的SMCs与AD相关的脑萎缩、神经退行性变的血浆生物标志物以及纵向认知和功能衰退的相关性更强。基线PRMQ增加10分使诊断进展的年度风险增加约70%。研究伴侣的人口统计学特征及其与参与者的关系仅影响AD参与者的SMCs报告。
使用PRMQ，伴侣报告的SMCs与AD相关的神经解剖学和认知变化的关系比患者报告的SMCs更强。需要进一步开展工作来评估SMCs是否可用于筛查未来的衰退情况。
