Jiang Shaofan, Cheng Yingzhe, Jiang Rifeng, Huang Peilin, Zhang Jiejun, Pan Xiaodong, Xue Yunjing
Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.
Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Brain Behav. 2025 Aug;15(8):e70777. doi: 10.1002/brb3.70777.
Scarce studies have elucidated the relationship between the microstructure changes of white matter (WM) and cognitive domains in overweight (OW). This study aimed to evaluate the WM microstructure changes and the relationship with the cognitive domains and cognition-related plasma biomarkers.
This study recruited 77 standard weight (SW) and 42 OW participants. The WM integrity was analyzed using neurite orientation dispersion and density imaging (NODDI) and diffusion tensor imaging (DTI). The region of interest (ROI) values of NODDI and DTI were calculated and compared between groups. The correlations between WM microstructure and cognitive domains and cognition-related plasma biomarkers were also recorded.
The ROI analysis revealed significant differences in fractional anisotropy (FA) and orientation dispersion index (ODI) in extensive WM regions (p < 0.05). Further analysis showed that NODDI parameter values of the uncinate fasciculus (UF) showed significant correlations with the cognitive domain. Additionally, other abnormal WM microstructures of OW were associated with cognitive domains and cognition-related plasma biomarkers to varying degrees.
The findings evidence that abnormalities of the WM microstructure may indicate typical changes of OW, and these microstructure abnormalities are associated with cognitive functions and cognition-related plasma biomarkers.
鲜有研究阐明超重（OW）人群中白质（WM）微观结构变化与认知领域之间的关系。本研究旨在评估WM微观结构变化及其与认知领域和认知相关血浆生物标志物的关系。
本研究招募了77名标准体重（SW）参与者和42名OW参与者。使用神经突方向离散度与密度成像（NODDI）和扩散张量成像（DTI）分析WM完整性。计算并比较两组之间NODDI和DTI的感兴趣区（ROI）值。还记录了WM微观结构与认知领域和认知相关血浆生物标志物之间的相关性。
ROI分析显示，在广泛的WM区域中，分数各向异性（FA）和方向离散度指数（ODI）存在显著差异（p < 0.05）。进一步分析表明，钩束（UF）的NODDI参数值与认知领域显著相关。此外，OW的其他异常WM微观结构与认知领域和认知相关血浆生物标志物存在不同程度的关联。
研究结果表明，WM微观结构异常可能表明OW的典型变化，并且这些微观结构异常与认知功能和认知相关血浆生物标志物有关。
