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空间导航问卷作为早期阿尔茨海默病的辅助诊断工具

Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease.

作者信息

Laczó Martina, Svatkova Radka, Lerch Ondrej, Martinkovic Lukas, Zuntychova Terezie, Nedelska Zuzana, Horakova Hana, Vyhnalek Martin, Hort Jakub, Laczó Jan

机构信息

Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.

出版信息

iScience. 2024 Apr 26;27(6):109832. doi: 10.1016/j.isci.2024.109832. eCollection 2024 Jun 21.

DOI:10.1016/j.isci.2024.109832
PMID:38779476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11108981/
Abstract

Impaired spatial navigation is early marker of Alzheimer's disease (AD). We examined ability of self- and informant-reported navigation questionnaires to discriminate between clinically and biomarker-defined participants, and associations of questionnaires with navigation performance, regional brain atrophy, AD biomarkers, and biomarker status. 262 participants (cognitively normal, with subjective cognitive decline, amnestic mild cognitive impairment [aMCI], and mild dementia) and their informants completed three navigation questionnaires. Navigation performance, magnetic resonance imaging volume/thickness of AD-related brain regions, and AD biomarkers were measured. Informant-reported questionnaires distinguished between cognitively normal and impaired participants, and amyloid-β positive and negative aMCI. Lower scores were associated with worse navigation performance, greater atrophy in AD-related brain regions, and amyloid-β status. Self-reported questionnaire scores did not distinguish between the groups and were weakly associated with navigation performance. Other associations were not significant. Informant-reported navigation questionnaires may be a screening tool for early AD reflecting atrophy of AD-related brain regions and AD pathology.

摘要

空间导航受损是阿尔茨海默病（AD）的早期标志物。我们研究了自我报告和他人报告的导航问卷区分临床和生物标志物定义参与者的能力，以及问卷与导航表现、脑区萎缩、AD生物标志物和生物标志物状态之间的关联。262名参与者（认知正常、主观认知下降、遗忘型轻度认知障碍[aMCI]和轻度痴呆）及其信息提供者完成了三份导航问卷。测量了导航表现、与AD相关脑区的磁共振成像体积/厚度以及AD生物标志物。他人报告的问卷能够区分认知正常和受损的参与者，以及淀粉样蛋白-β阳性和阴性的aMCI。较低的分数与较差的导航表现、AD相关脑区更严重的萎缩以及淀粉样蛋白-β状态相关。自我报告的问卷分数无法区分各组，且与导航表现的关联较弱。其他关联不显著。他人报告的导航问卷可能是一种反映AD相关脑区萎缩和AD病理的早期AD筛查工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/9ea32d58ba7f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/2b447322836e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/7d32323b0698/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/d95d3439e975/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/230abd353a25/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/48b88decb5ec/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/9ea32d58ba7f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/2b447322836e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/7d32323b0698/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/d95d3439e975/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/230abd353a25/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/48b88decb5ec/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1252/11108981/9ea32d58ba7f/gr5.jpg

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