Chen Y
Biophys Chem. 1987 Jul;27(1):59-65. doi: 10.1016/0301-4622(87)80046-7.
A general formalism is derived for the evaluation of binding isotherms of n-mers (ligands) to one-dimensional polymers in the presence of ligand-ligand interactions which extend over several binding sites with distance-dependent interaction energies (multi-parameter model). This is an extension of the usual n-mer binding theory developed by several investigators in which ligand-ligand interaction occurs only when two ligands are in close contact (one-parameter model). The difference in binding isotherms between a one-parameter model and a multi-parameter model is studied numerically using the present formalism.
推导了一种通用形式，用于评估在配体 - 配体相互作用存在的情况下，n聚体（配体）与一维聚合物的结合等温线。这种相互作用延伸到几个具有距离依赖性相互作用能的结合位点（多参数模型）。这是几位研究者所发展的通常n聚体结合理论的扩展，在该理论中，配体 - 配体相互作用仅在两个配体紧密接触时发生（单参数模型）。使用当前形式对单参数模型和多参数模型之间结合等温线的差异进行了数值研究。
