输血对化疗治疗白血病患者血小板参数变化的影响分析
The Analysis of the Effect of Blood Transfusion on Changes of Blood Platelet Parameters in Patients with Leukemia Treated with Chemotherapy.
作者信息
He Yangxin, Liang Shanshan, Xu Yali, Wan Chunjing, Ma Feng, Wang Baoyan
机构信息
Department of Blood Transfusion, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shannxi, China.
出版信息
Evid Based Complement Alternat Med. 2022 Aug 29;2022:2901993. doi: 10.1155/2022/2901993. eCollection 2022.
OBJECTIVE
To study and analyze the effect of blood transfusion on the change of blood platelet parameters in patients with leukemia treated with chemotherapy.
METHODS
Ninety-eight patients with leukemia treated with chemotherapy in the First Affiliated Hospital of Xi'an Jiaotong University from January 2021 to January 2022 were selected to observe the changes of platelet parameters before and after blood transfusion.
RESULTS
There was significant difference between pre-transfusion and post-transfusion indexes (platelet count, mean platelet volume, and hematocrit) ( < 0.05). After binary logistic regression analysis, the use of antibiotics (OR = 2.235), blood transfusion history (OR = 3.086), abnormal white blood cell count (OR = 1.134), and frozen plasma transfusion (OR = 3.121) were the main factors of blood platelet parameters after transfusion in leukemia patients ( < 0.05).
CONCLUSION
Blood transfusion is beneficial to improve blood platelet parameters and prevent bleeding in patients with leukemia treated with chemotherapy. Attention should be paid to patients with risk factors for poor response to blood platelet transfusion and early intervention.
目的
研究分析输血对化疗白血病患者血小板参数变化的影响。
方法
选取2021年1月至2022年1月在西安交通大学第一附属医院接受化疗的98例白血病患者，观察输血前后血小板参数的变化。
结果
输血前后指标（血小板计数、平均血小板体积和血细胞比容）差异有统计学意义（<0.05）。二元logistic回归分析后，使用抗生素（OR = 2.235）、输血史（OR = 3.086）、白细胞计数异常（OR = 1.134）和输注冰冻血浆（OR = 3.121）是白血病患者输血后血小板参数的主要影响因素（<0.05）。
结论
输血有利于改善化疗白血病患者的血小板参数并预防出血。应关注血小板输血反应不佳危险因素的患者并进行早期干预。
Zotero 插件