Yang Yu, Chen Shenglan, Wu Xiaoxuan, Peng Li, Vílchez Juan I, Kaushal Richa, Liu Xiaomin, Singh Sunil K, He Danxia, Yuan Fengtong, Lv Suhui, Morcillo Rafael J L, Wang Wei, Huang Weichang, Lei Mingguang, Zhu Jian-Kang, Paré Paul W, Zhang Huiming
Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Natl Sci Rev. 2022 Jun 10;9(8):nwac109. doi: 10.1093/nsr/nwac109. eCollection 2022 Aug.
Unlike microbe-associated molecular patterns (MAMPs) that are readily targeted by host immunity, microbial non-pathogenic factors (NPFs) appear negligible as they do not elicit defense. Little is known about whether and how NPFs may be monitored by hosts to control compatibility. Herein, a forward genetic screening isolated an Arabidopsis mutant with a loss of plant-rhizobacteria mutualism, leading to the disclosure of a plant latent defense response (LDR) to NPFs. The activation of LDR in the mutant, named for , is triggered by several non-pathogenic volatile organic compounds and antagonizes plant compatibility with the beneficial bacterium GB03. The activation of LDR in is mediated through the prokaryotic pathway of chloroplastic lipid biosynthesis. The root microbiome showed a reduced proportion of the family. We propose that, parallel to the forefront immunity to MAMPs, LDR to certain NPFs provides a hidden layer of defense for controlling compatibility with commensal or beneficial microbes.
与易被宿主免疫系统靶向的微生物相关分子模式（MAMPs）不同，微生物非致病因子（NPFs）似乎微不足道，因为它们不会引发防御反应。关于宿主是否以及如何监测NPFs以控制兼容性，人们知之甚少。在此，一项正向遗传学筛选分离出了一个丧失植物与根际细菌共生关系的拟南芥突变体，从而揭示了植物对NPFs的潜在防御反应（LDR）。在以 命名的突变体中，LDR的激活由几种非致病性挥发性有机化合物触发，并拮抗植物与有益细菌GB03的兼容性。 中LDR的激活是通过叶绿体脂质生物合成的原核途径介导的。 的根微生物群中 科的比例降低。我们提出，与对MAMPs的前沿免疫并行，对某些NPFs的LDR为控制与共生或有益微生物的兼容性提供了一层隐藏的防御。
