中医体质类型与不同地区肺癌的相关性：系统评价和荟萃分析。

Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis.

机构信息

Center for Treatment of Diseases, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China.

Ophthalmology Department, Jiangxi Integrated Hospital of Traditional Chinese and Western Medicine, Nanchang, Jiangxi, China.

出版信息

Contrast Media Mol Imaging. 2022 Aug 17;2022:5660231. doi: 10.1155/2022/5660231. eCollection 2022.

DOI:10.1155/2022/5660231

PMID:36072639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9402362/

Abstract

BACKGROUND

Lung carcinoma is a serious disorder that negatively influences the quality of life of sufferers. Despite the growing number of investigations into the management and prognosis of lung carcinoma, few research studies have been conducted to demonstrate the association between TCM constitution and lung carcinoma.

METHODS

We searched PubMed, EMBASE, Science Net, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biomedical Literature Database for Chinese and English versions until January 31, 2021. We also manually searched for Chinese lung cancer, Chinese physical medicine, Chinese medical trial registries, and unpublished surveys or references. The literature was screened against inclusive and exclusive criteria, and two investigators' results were independently summarized. The primary outcome was a ratio of body type. Single-group rates were meta-analyzed using Stata 14.0 statistical software, bias was estimated by funnel plotting, and sources of heterogeneity were evaluated by subgroup and sensitivity examinations.

RESULTS

18 randomized controlled trials were totally included to compare the single-group ratio and 95% confidence interval of nine constitution types of lung cancer, namely, mild constitution (ES = 0.12, 95% CI (0.08, 0.15), < 0.0001), Qi deficiency constitution (ES = 0.20, 95% CI (0.15, 0.26), < 0.0001), Qi depression constitution (ES = 0.09, 95% CI (0.07, 0.12), < 0.0001), damp-heat constitution (ES = 0.05, 95% CI (0.03, -0.06), < 0.0001), phlegm dampness constitution (ES = 0.05, 95% CI (0.03, -0.06), < 0.0001), special constitution (ES = 0.01, 95% CI (0.01, 0.02), =0.993), blood stasis constitution (ES = 0.05, 95% CI (0.04, 0.07), < 0.0001), Yang deficiency constitution (ES = 0.16, 95% CI (0.12, 0.19), < 0.0001), and Yin deficiency constitution (MD = 0.15, 95% CI (0.11, 0.18), < 0.0001).

CONCLUSION

This study showed that Qi deficiency, Yang deficiency, and Yin vacuity were the predominant types of physical conditions of lung cancer cases.

摘要

背景

肺癌是一种严重的疾病，会降低患者的生活质量。尽管越来越多的研究致力于肺癌的管理和预后，但很少有研究表明中医体质与肺癌之间的关系。

方法

我们检索了 PubMed、EMBASE、Science Net、Cochrane Library、中国知网、维普数据库、万方数据库和中国生物医学文献数据库中的中英文文献，检索截至 2021 年 1 月 31 日。我们还手动检索了中文肺癌、中医体质学、中国临床试验注册中心以及未发表的调查或参考文献。根据纳入和排除标准筛选文献，由两名研究者独立总结结果。主要结局指标为体型比。使用 Stata 14.0 统计软件对单组率进行 meta 分析，通过漏斗图估计偏倚，并通过亚组和敏感性检验评估异质性来源。

结果

共纳入 18 项随机对照试验比较 9 种肺癌体质类型的单组率和 95%置信区间，即：平和质（ES=0.12，95%CI（0.08，0.15），<0.0001）、气虚质（ES=0.20，95%CI（0.15，0.26），<0.0001）、气郁质（ES=0.09，95%CI（0.07，0.12），<0.0001）、湿热质（ES=0.05，95%CI（0.03，-0.06），<0.0001）、痰湿质（ES=0.05，95%CI（0.03，-0.06），<0.0001）、特禀质（ES=0.01，95%CI（0.01，0.02），=0.993）、血瘀质（ES=0.05，95%CI（0.04，0.07），<0.0001）、阳虚质（ES=0.16，95%CI（0.12，0.19），<0.0001）和阴虚质（MD=0.15，95%CI（0.11，0.18），<0.0001）。