Deputy Director of Obstetrics and Gynecology Hospital, Second People's Hospital of Gansu Province Affiliated Hospital of Northwest University for Nationalities, Lanzhou 730000, China.
Attending Doctor of Obstetrics and Gynecology, Gansu Family Planning Science and Technology Service Center, Lanzhou 730000, China.
Contrast Media Mol Imaging. 2022 Aug 17;2022:6112659. doi: 10.1155/2022/6112659. eCollection 2022.
Based on hypoxia-inducible factor-1 (HIF-1), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and anti-Mullerian hormone (AMH), the antral follicle is explored. The expression of count (AFC) in females at lofty elevation and its clinical significance are analyzed. A total of 82 females in lofty elevation areas and in low-elevation areas who received health checks from April 2020 to May 2021 are selected as the lofty elevation set and the low-elevation set, respectively. In addition, 76 females are served as the routine set. By comparing the serum HIF-1 standards, the standards of sex hormone indexes FSH, LH, and E2, and the expressions of AMH and AFC between the two sets of females, the correlation between HIF-1 and sex hormone indexes and ovarian reserve function is analyzed. The experimental results show that the lofty standard of HIF-1 in females at lofty elevation may lead to abnormal standards of sex hormones and weakened ovarian reserve. The detection of HIF-1 in females in lofty elevation areas is of great significance for evaluating their sex hormone standards, ovarian function, and preventing the occurrence of female gynecological diseases.
基于缺氧诱导因子-1（HIF-1）、卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）和抗苗勒管激素（AMH）来探讨窦卵泡。分析高海拔地区女性的窦卵泡计数（AFC）表达及其临床意义。选取 2020 年 4 月至 2021 年 5 月在高海拔地区和低海拔地区接受健康检查的 82 名女性作为高海拔组和低海拔组，另选 76 名女性作为常规组。通过比较两组女性的血清 HIF-1 标准、性激素指标 FSH、LH 和 E2 的标准以及 AMH 和 AFC 的表达，分析 HIF-1 与性激素指标和卵巢储备功能的相关性。实验结果表明，高海拔地区女性的 HIF-1 高海拔标准可能导致性激素水平异常和卵巢储备功能减弱。检测高海拔地区女性的 HIF-1 对评估其性激素水平、卵巢功能以及预防女性妇科疾病的发生具有重要意义。
