Department of Neurology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China.
Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China.
Mol Med Rep. 2017 Dec;16(6):8209-8215. doi: 10.3892/mmr.2017.7668. Epub 2017 Sep 29.
The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampus (HP), substantia nigra, red nucleus (RN), dentate nucleus (DN), caudate nucleus (CN), globus pallidus (GP), putamen (PUT), frontal white matter, temporal cortex (TC), and parietal cortex. Body iron indices, including serum iron, serum transferrin, ferritin and total iron binding capacity, were measured. Phase values of the left (L)‑DN, L‑CN, and bilateral PUT in the MCI group were significantly lower compared with NC group. Phase values of the right (R)‑RN, bilateral DN, and bilateral PUT in the AD group were significantly lower compared with the MCI group. Phase values of the bilateral HP, DN, RN, CN, GP, PUT, and L‑TC in the AD group were significantly lower compared with the NC group. Serum ferritin levels in the MCI and AD groups were significantly lower compared with the NC group. Only serum iron in the AD group was positively associated with iron content in the R‑HP. Brain iron deposition and body iron levels both increased in MCI and AD patients, however, excessive brain iron accumulation may have no association with body iron level. SWI was particularly effective at recognizing the presence of brain iron in the MCI and AD groups.
本研究旨在分析轻度认知障碍（MCI）、阿尔茨海默病（AD）和正常对照组（NC）患者的脑铁和体铁水平。共纳入 90 名参与者（30 名 MCI、30 名 AD、30 名 NC）。采用磁敏感加权成像（SWI）定量脑铁含量。相位值用于计算海马（HP）、黑质、红核（RN）、齿状核（DN）、尾状核（CN）、苍白球（GP）、壳核（PUT）、额白质、颞叶皮质（TC）和顶叶皮质的双侧铁含量。测量体铁指标，包括血清铁、血清转铁蛋白、铁蛋白和总铁结合力。与 NC 组相比，MCI 组左（L）-DN、L-CN 和双侧 PUT 的相位值明显降低。与 MCI 组相比，AD 组右（R）-RN、双侧 DN 和双侧 PUT 的相位值明显降低。与 NC 组相比，AD 组双侧 HP、DN、RN、CN、GP、PUT 和双侧 TC 的相位值明显降低。与 NC 组相比，MCI 和 AD 组的血清铁蛋白水平明显降低。仅 AD 组的血清铁与 R-HP 的铁含量呈正相关。MCI 和 AD 患者的脑铁沉积和体铁水平均增加，但过量的脑铁积累可能与体铁水平无关。SWI 特别有效地识别 MCI 和 AD 组脑铁的存在。
