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2型糖尿病患者的抑郁症及相关危险因素:来自沙特阿拉伯哈米斯穆谢特糖尿病中心便利样本的横断面研究

Depression and Associated Risk Factors Among Type 2 Diabetic Patients: A Cross Sectional Study on a Convenience Sample from the Diabetic Center, Khamis Mushait; Saudi Arabia.

作者信息

Abuhegazy Hesham, Mujairi Ahoud, Banah Faisal, Agdi Yasir, Elkeshishi Heba, Kamel Ahmed, Abdullah Ahmed, Elsheikh Mohamed

机构信息

Department of Psychiatry, faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Department of Family Medicine, Ministry of Health, Jazan, Saudi Arabia.

出版信息

Neuropsychiatr Dis Treat. 2022 Aug 31;18:1975-1984. doi: 10.2147/NDT.S374752. eCollection 2022.

Abstract

BACKGROUND

Studies had confirmed that diabetic patients have a greater risk for developing depression. Our objectives were to estimate the prevalence and predictors of depression among type 2 diabetic patients.

METHODS

A cross-sectional study at the Diabetic Center, Armed Forces Hospital-Southern Region (AFHSR), Khamis Mushait was conducted in the period from March to June 2017. The study includes a convenience sample of type 2 diabetic patients. Self-administered questionnaires were utilized. It consists of personal characteristics, diabetes-related information's, and the Arabic version of the Patient Health Questionnaire (PHQ-9). Proper statistical analyses were done to assess the significance of the correlates with p ≤ 0.05 considered significant.

RESULTS

The study included 350 diabetic patients out of 410 with a response rate of 85.4%. Their age ranged between 28 and 100 years with a mean ±SD of 61.4±13 years. The prevalence of depression among them was 36.6%. Logistic regression revealed that patients older than 50 years were at lower risk for developing depression as compared to those aged between 28 and 40 years OR and 95% CI were 0.21 (0.08-0.57), 0.30 (0.12-0.78) and 0.33 (0.12-0.91) for patients in the age groups 51-60, 61-70 and > 70 years, respectively. Diabetic patients with thyroid dysfunction, neuropathy, those treated with insulin, and noncompliant patients were at double risk for developing depression compared to their counterparts (OR = 2.26, 95% CI = 1.20-4.27, p = 0.012); (OR = 2.35, 95% CI = 1.22-4.53, p = 0.011); (OR = 1.92, 95% CI = 1.08-3.40, p = 0.026); (AOR = 2.14, 95% CI = 1.01-4.53, p = 0.047) respectively.

CONCLUSION

Almost one third of type 2 diabetic patients were depressed. Younger patients, having comorbid thyroid disorders or neuropathy, those treated with insulin and noncompliant patients were at higher risk for developing depression. Proper screening and treatment of depression is a crucial part of the health care management of diabetic people.

摘要

背景

研究已证实糖尿病患者患抑郁症的风险更高。我们的目标是评估2型糖尿病患者中抑郁症的患病率及预测因素。

方法

2017年3月至6月期间,在哈米斯穆沙特的武装部队医院南区糖尿病中心进行了一项横断面研究。该研究纳入了2型糖尿病患者的便利样本。采用自行填写的问卷。问卷包括个人特征、糖尿病相关信息以及患者健康问卷(PHQ - 9)的阿拉伯语版本。进行了适当的统计分析以评估相关性的显著性,p≤0.05被视为具有显著性。

结果

该研究纳入了410名患者中的350名糖尿病患者,应答率为85.4%。他们的年龄在28岁至100岁之间,平均±标准差为61.4±13岁。其中抑郁症的患病率为36.6%。逻辑回归显示,与年龄在28岁至40岁之间的患者相比,50岁以上的患者患抑郁症的风险较低,51 - 60岁、61 - 70岁和>70岁年龄组患者的比值比(OR)及95%置信区间(CI)分别为0.21(0.08 - 0.57)、0.30(0.12 - 0.78)和0.33(0.12 - 0.91)。与对照组相比,患有甲状腺功能障碍、神经病变的糖尿病患者、接受胰岛素治疗的患者以及不遵医嘱的患者患抑郁症的风险加倍(OR = 2.26,95% CI = 1.20 - 4.27,p = 0.012);(OR = 2.35,95% CI = 1.22 - 4.53,p = 0.011);(OR = 1.92,95% CI = 1.08 - 3.40,p = 0.026);(调整后比值比[AOR] = 2.14,95% CI = 1.01 - 4.53,p = 0.047)。

结论

几乎三分之一的2型糖尿病患者患有抑郁症。年轻患者、患有甲状腺疾病或神经病变合并症的患者、接受胰岛素治疗的患者以及不遵医嘱的患者患抑郁症的风险更高。对抑郁症进行适当的筛查和治疗是糖尿病患者医疗管理的关键部分。

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