甲状腺功能与抑郁症之间的联系。
The Link between Thyroid Function and Depression.
作者信息
Hage Mirella P, Azar Sami T
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon.
出版信息
J Thyroid Res. 2012;2012:590648. doi: 10.1155/2012/590648. Epub 2011 Dec 14.
Abstract
The relation between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4 levels, low T3, elevated rT3, a blunted TSH response to TRH, positive antithyroid antibodies, and elevated CSF TRH concentrations. In addition, thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressant drugs. However, the mechanisms underlying the interaction between thyroid function and depression remain to be further clarified. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship.
摘要
甲状腺功能与抑郁症之间的关系早已为人所知。甲状腺疾病患者更容易出现抑郁症状，反之，抑郁症可能伴有各种细微的甲状腺异常。传统上，最常记录到的异常包括T4水平升高、T3降低、反T3升高、促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）反应迟钝、抗甲状腺抗体阳性以及脑脊液中TRH浓度升高。此外，甲状腺激素补充剂似乎能加速并增强对抗抑郁药物的临床反应。然而，甲状腺功能与抑郁症之间相互作用的潜在机制仍有待进一步阐明。最近，生物化学、遗传学和神经影像学领域的进展为甲状腺与抑郁症的关系提供了新的见解。
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Panminerva Med. 2010 Dec;52(4):277-82.
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Behav Brain Res. 2010 Dec 25;214(2):187-92. doi: 10.1016/j.bbr.2010.05.016. Epub 2010 May 16.
3
Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy.甲状腺功能减退症患者的脑葡萄糖代谢：甲状腺激素替代治疗前后的正电子发射断层扫描研究
J Clin Endocrinol Metab. 2009 Aug;94(8):2922-9. doi: 10.1210/jc.2008-2235. Epub 2009 May 12.
4
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J Clin Endocrinol Metab. 2009 May;94(5):1623-9. doi: 10.1210/jc.2008-1301. Epub 2009 Feb 3.
5
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Int Clin Psychopharmacol. 2009 Jan;24(1):19-25. doi: 10.1097/YIC.0b013e328314dfaf.
6
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Can J Psychiatry. 2008 Dec;53(12):833-8. doi: 10.1177/070674370805301209.
7
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J Affect Disord. 2009 Jul;116(1-2):113-6. doi: 10.1016/j.jad.2008.10.019. Epub 2008 Dec 6.
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9
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