Delépine N, Delépine G, Desbois J C, Mathé G, Legmann F
Biomed Pharmacother. 1987;41(3):146-8.
Six patients with inoperable desmoid tumors have been treated by preoperative chemotherapy. In all six cases objective response occurred and allowed conservative surgery. Objective responses included tumor softening (6/6), releasing of articular motion previously limited (3/3), and tumor size' decreasing (2/6). Few histologic modifications were seen. Such data advocates for preoperative chemotherapy in desmoid tumor when large and threatening the limb or the life of the patient.
6例无法手术切除的硬纤维瘤患者接受了术前化疗。所有6例患者均出现客观缓解，并得以进行保守手术。客观缓解包括肿瘤软化（6/6）、先前受限的关节活动恢复（3/3）以及肿瘤大小缩小（2/6）。组织学改变较少。这些数据支持对于体积较大且威胁肢体或患者生命的硬纤维瘤进行术前化疗。
