Pincus S H, Ramesh K S, Wyler D J
Blood. 1987 Aug;70(2):572-4.
Fibrosis complicates a number of chronic inflammatory diseases and occurs in some conditions following chronic hypereosinophilic syndromes. We assessed whether eosinophils might be a source of fibrogenic factors. Extracts of human and guinea pig cell populations enriched for eosinophils contained substances that stimulated tritiated thymidine incorporation by human fibroblasts. Supernatants derived from resting eosinophils and extracts prepared from eosinophil granules also contained fibrogenic factors. Our findings demonstrate a new potential role for eosinophils and suggest a causal relationship between tissue eosinophilia and scar formation in certain parasitic conditions.
纤维化使多种慢性炎症性疾病复杂化，并且在慢性嗜酸性粒细胞增多综合征后的某些情况下出现。我们评估了嗜酸性粒细胞是否可能是促纤维化因子的来源。富含嗜酸性粒细胞的人和豚鼠细胞群体提取物含有刺激人成纤维细胞掺入氚化胸腺嘧啶核苷的物质。来自静息嗜酸性粒细胞的上清液和从嗜酸性粒细胞颗粒制备的提取物也含有促纤维化因子。我们的研究结果证明了嗜酸性粒细胞的一种新的潜在作用，并提示在某些寄生虫病情况下组织嗜酸性粒细胞增多与瘢痕形成之间存在因果关系。
