Raetzo M A, Junod A F, Kryger M H
Bull Eur Physiopathol Respir. 1987 Mar-Apr;23(2):171-5.
A 17-year old boy presented with severe, predominantly central sleep apnoeas secondary to structural damage in the medulla. At low O2 saturation, the electroencephalogram showed the sudden onset of slow waves. Hypercapnic ventilatory response was low and hypoxic ventilatory response was absent. Low flow oxygen therapy dramatically improved the apnoea score, probably by relieving hypoxic brain depression. Slow waves also disappeared with oxygen therapy. Aminophylline was effective on apnoea score and duration (p less than 0.001). This beneficial effect could be explained by an improvement of the normal oscillations of respiration at the onset of sleep, a change in arousability or a stimulation of the ascending reticular system. These findings suggest a possible role of hypoxic depression in the manifestations of central sleep apnoeas and demonstrate the beneficial effect of low flow oxygen and aminophylline in treating certain central sleep apnoeas.
一名17岁男孩因延髓结构损伤继发严重的、主要为中枢性睡眠呼吸暂停。在低氧饱和度时，脑电图显示慢波突然出现。高碳酸血症通气反应低，低氧通气反应缺失。低流量氧疗显著改善了呼吸暂停评分，可能是通过减轻缺氧性脑抑制实现的。氧疗时慢波也消失了。氨茶碱对呼吸暂停评分和持续时间有效（P<0.001）。这种有益作用可以通过睡眠开始时呼吸正常振荡的改善、唤醒能力的改变或对上行网状系统的刺激来解释。这些发现提示缺氧性抑制在中枢性睡眠呼吸暂停表现中可能起作用，并证明低流量氧和氨茶碱在治疗某些中枢性睡眠呼吸暂停中的有益作用。
