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特定识别优先级的单独评分算法可优化幼儿自闭症筛查工具(STAT)的筛查特性。

Separate scoring algorithms for specific identification priorities optimize the screening properties of the Screening Tool for Autism in Toddlers (STAT).

机构信息

University of Washington, Seattle, Washington, USA.

出版信息

Autism Res. 2022 Nov;15(11):2069-2080. doi: 10.1002/aur.2799. Epub 2022 Sep 8.

Abstract

The Screening Tool for Autism in Toddlers (STAT) is a validated stage-2 autism spectrum disorder (ASD) screening measure that takes 20 minutes to administer and comprises 12 play-based items that are scored according to specific criteria. This study examines an expanded version (STAT-E) that includes the examiner's subjective ratings of children's social engagement (SE) and atypical behaviors (AB) in the scoring algorithm. The sample comprised 238 children who were 24-35 months old. The STAT-E assessors had limited ASD experience to mimic its use by community-based non-specialists, and were trained using a scalable web-based platform. A diagnostic evaluation was completed by clinical experts who were blind to the STAT-E results. Logistic regression, ROC curves, and classification matrices and metrics were used to determine the screening properties of STAT-E when scored using the original STAT scoring algorithm versus a new algorithm that included the SE and AB ratings. Inclusion of the SE and AB ratings improved positive risk classification appreciably, while the specificity declined. These results suggest that the STAT-E using the original STAT scoring algorithm optimizes specificity, while the STAT-E scoring algorithm with the two new ratings optimizes the positive risk classification. Using multiple scoring algorithms on the STAT may provide improved screening accuracy for diverse contexts, and a scalable web-based tutorial may be a pathway for increasing the number of community providers who can administer the STAT and contribute toward increased rates of autism screening.

摘要

《幼儿自闭症筛查工具(STAT)》是一种经过验证的第二阶段自闭症谱系障碍(ASD)筛查工具,其评估时长为 20 分钟,包含 12 项基于游戏的项目,这些项目根据特定标准进行评分。本研究考察了一种扩展版本(STAT-E),其中包括评估者对儿童社会参与度(SE)和异常行为(AB)的主观评分,这些评分纳入了评分算法。样本包括 238 名年龄在 24-35 个月的儿童。STAT-E 评估者对 ASD 仅有有限的经验,旨在模拟社区非专业人士的使用方式,并且使用可扩展的基于网络的平台进行培训。临床专家进行了诊断评估,他们对 STAT-E 的结果一无所知。使用逻辑回归、ROC 曲线、分类矩阵和指标来确定 STAT-E 的筛查特性,分别使用原始 STAT 评分算法和包含 SE 和 AB 评分的新算法进行评分。纳入 SE 和 AB 评分显著提高了阳性风险分类,而特异性下降。这些结果表明,使用原始 STAT 评分算法的 STAT-E 优化了特异性,而包含两个新评分的 STAT-E 评分算法优化了阳性风险分类。在 STAT 上使用多种评分算法可能会提高不同环境下的筛查准确性,而基于网络的可扩展教程可能是增加能够管理 STAT 并提高自闭症筛查率的社区提供者数量的途径。

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