Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Nicotine Tob Res. 2023 Feb 9;25(3):498-504. doi: 10.1093/ntr/ntac211.
POD electronic nicotine delivery systems (ENDS), often containing high concentrations of nicotine salts, have replaced MODs (ie, open/modifiable devices) as the most popular devices. The purpose of this study was to compare device/liquid characteristics, use behavior, and nicotine exposure between POD and MOD users.
Data from the initial visit of a prospective observational study of exclusive ENDS users compared MOD (n = 48) and POD (n = 37) users. Participants completed questionnaires on demographic characteristics, patterns of ENDS use, and ENDS features. A urine sample was collected to test for cotinine and an ENDS liquid sample was collected to test for nicotine and salts. Puff topography was captured during an ad libitum bout at the end of the session.
MOD and POD users did not differ on demographic characteristics. MOD users reported purchasing more liquid in the past month than POD users (180.4 ± 28.0 vs. 50.9 ± 9.0 ml, p < .001). Differences in characteristics of devices used by MOD and POD users included flavor type (p = .029), nicotine concentration (liquids used by MOD users contained less nicotine than those used by POD users: 8.9 ± 2.0 vs. 41.6 ± 3.2 mg/ml, p < .001), and presence of the nicotine salt (fewer MOD liquids had salts present than POD liquids: 11.9% vs. 77.4%, p < .001). User groups did not differ on urinary cotinine levels or puff topography (ps > .05).
Despite different characteristics of MOD and POD ENDS, users of those products are exposed to similar amounts of nicotine, likely due to using more liquid among MOD users.
This study directly compares ENDS product characteristics, user behavior, and nicotine exposure between MOD and POD ENDS users. Although POD products contained higher nicotine concentrations compared to MOD products, users of PODs reported consuming less liquid than MOD users. Ultimately, MOD and POD users were exposed to similar levels of nicotine, suggesting users behaviorally compensate for differences in product characteristics.
POD 型电子烟（ENDS），通常含有高浓度的尼古丁盐，已取代调制型电子烟（即开放式/可调节设备），成为最受欢迎的设备。本研究旨在比较 POD 和 MOD 用户在设备/液体特性、使用行为和尼古丁暴露方面的差异。
该研究是一项专门针对 POD 和 MOD 用户的前瞻性观察研究的初始访问数据，将 48 名 MOD 用户和 37 名 POD 用户纳入比较。参与者完成了关于人口统计学特征、电子烟使用模式和电子烟特征的问卷。采集尿液样本以检测可替宁，采集电子烟液体样本以检测尼古丁和盐。在会议结束时进行自由抽吸时，记录抽吸特征。
MOD 和 POD 用户在人口统计学特征方面无差异。MOD 用户报告过去一个月购买的液体量多于 POD 用户（180.4±28.0 与 50.9±9.0 毫升，p<0.001）。MOD 和 POD 用户使用的设备特征存在差异，包括口味类型（p=0.029）、尼古丁浓度（MOD 用户使用的液体尼古丁含量低于 POD 用户：8.9±2.0 与 41.6±3.2 毫克/毫升，p<0.001），以及是否含有尼古丁盐（MOD 液体中含有盐的比例低于 POD 液体：11.9%比 77.4%，p<0.001）。两组在尿可替宁水平或抽吸特征方面无差异（p>0.05）。
尽管 MOD 和 POD 型电子烟具有不同的特点，但使用这些产品的用户暴露于相似量的尼古丁，这可能是由于 MOD 用户使用更多的液体。
本研究直接比较了 MOD 和 POD 型电子烟的产品特征、用户行为和尼古丁暴露情况。尽管 POD 产品的尼古丁浓度高于 MOD 产品，但 POD 用户报告的液体摄入量低于 MOD 用户。最终，MOD 和 POD 用户暴露于相似水平的尼古丁，这表明用户通过行为来弥补产品特征的差异。
