Höpp H P, Reuter G, Reiser G, Hamprecht B
Brain Res. 1987 May 26;412(1):175-8. doi: 10.1016/0006-8993(87)91456-9.
Angiotensins I, II and III induced a hyperpolarizing response of up to 1 min duration followed by a depolarizing response of up to 4 min when applied by pressure pulses or iontophoresis to polyploid rat glioma cells C6-4-2. The hyperpolarization (depolarization) was associated with a 50% decrease (no measurable change) in membrane resistance. The reversal potential (ca.-90 mV) of the hyperpolarization most likely points to an increase K+ conductance. Cells desensitized to angiotensins on application of high doses of either angiotensins or bradykinin.
当通过压力脉冲或离子电渗法将血管紧张素I、II和III施加到多倍体大鼠胶质瘤细胞C6-4-2时，会诱导出持续长达1分钟的超极化反应，随后是长达4分钟的去极化反应。超极化（去极化）与膜电阻降低50%（无明显变化）有关。超极化的反转电位（约为-90 mV）很可能表明钾离子电导增加。在应用高剂量的血管紧张素或缓激肽时，细胞会对血管紧张素产生脱敏作用。
