Laboratory of Aging, Anti-aging & Cognitive Performance, Shanghai Institute of Geriatrics and Gerontology, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Psychogeriatrics. 2022 Nov;22(6):822-832. doi: 10.1111/psyg.12889. Epub 2022 Sep 8.
To examine how the severity of age-related hearing loss (ARHL) and tinnitus or the presentation of ARHL with tinnitus is associated with overall cognition, in terms of specific cognitive domains in older community-dwelling Chinese adults.
The study recruited 429 participants aged ≥58 years (mean age, 72.91 ± 7.014 years; female proportion, 57.30%), excluding those with dementia, disability, and severe mental illness. Patients were classified into normal cognition, pre-mild cognitive impairment (pre-MCI), and MCI according to the normative z-scores of neuropsychological test battery. The severity of ARHL and tinnitus was measured by pure-tone audiometry and the Tinnitus Handicap Inventory. Cognitive impairment and low functions in specific cognitive domains were used as dependent variables in multiple regression analyses adjusted for covariates.
ARHL severity was positively associated with MCI and low executive function, delayed memory, and language function. Only individuals with mild (odds ratio (OR) 1.791; CI, 0.952-3.373; P = 0.071), and moderate and the disaster tinnitus (OR, 2.493; CI, 0.982-6.328; P = 0.055) were marginally associated with increased odds of MCI in model 1. Individuals with ARHL and tinnitus (OR, 3.888, CI = 1.481-10.205; OR, 4.471, CI = 1.636-12.219) were independently associated with high risk for MCI in models 1 and 2.
ARHL severity and the presentation of ARHL or ARHL with tinnitus were associated with overall cognition. ARHL severity was independently associated with executive function, delayed memory, and language function. The association between tinnitus severity and cognition is not clear. But the group with ARHL and tinnitus is a high-risk group with cognitive impairment.
gov identifier: NCT2017K020.
探讨老年听力损失（ARHL）的严重程度和耳鸣或 ARHL 伴耳鸣的表现与老年人整体认知之间的关系，特别是在特定认知领域的关系。
该研究招募了 429 名年龄≥58 岁（平均年龄 72.91±7.014 岁；女性比例 57.30%）的社区居住的中国成年人，排除痴呆、残疾和严重精神疾病患者。根据神经心理学测试包的规范 z 分数，患者被分为正常认知、轻度认知障碍前（pre-MCI）和 MCI。通过纯音测听和耳鸣残疾评估量表（Tinnitus Handicap Inventory）来测量 ARHL 和耳鸣的严重程度。将认知障碍和特定认知领域的低功能作为协变量调整后的多元回归分析的因变量。
ARHL 严重程度与 MCI 和执行功能、延迟记忆和语言功能降低呈正相关。只有轻度（优势比（OR）1.791；95%置信区间（CI），0.952-3.373；P=0.071）、中度和灾难样耳鸣（OR，2.493；95%CI，0.982-6.328；P=0.055）的个体在模型 1 中与 MCI 发生率增加的几率增加相关。在模型 1 和 2 中，患有 ARHL 和耳鸣的个体（OR，3.888，95%CI=1.481-10.205；OR，4.471，95%CI=1.636-12.219）与 MCI 风险升高独立相关。
ARHL 严重程度和 ARHL 或 ARHL 伴耳鸣的出现与整体认知有关。ARHL 严重程度与执行功能、延迟记忆和语言功能独立相关。耳鸣严重程度与认知之间的关系尚不清楚。但是，患有 ARHL 和耳鸣的群体是认知障碍的高风险群体。
gov 标识符：NCT0177K020。
