Department of Otolaryngology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Medicine (Baltimore). 2024 Jun 7;103(23):e38500. doi: 10.1097/MD.0000000000038500.
This study aimed to investigate the different impacts of sensorial and mobility frailty on overall and domain-specific cognitive function. Further, the independent associations between other intricate capacity (IC) dimensions, including vitality and psychological dimensions, and overall and domain-specific cognitive function were investigated. A total of 429 participants (mean age, 72.91 ± 7.014 years; 57.30% female) underwent IC capacity assessment. Other covariates, such as demographics, health-related variables were also assessed. Overall or domain-specific cognitive impairment was used as a dependent variable in logistic regression analyses adjusted for demographic, health-related, and psychosocial confounders. After adjustment for demographic, health-related, and psychosocial confounders, individuals with sensorial frailty (odds ratio [OR] = 0.435; 95% confidence interval [CI] = 0.236-0.801; P = .008) had a significantly lower risk of mild cognitive impairment (MCI), marginally low delayed memory impairment (OR = 0.601, 95% CI = 0.347-1.040; P = .069), and language impairment (OR = 0.534, 95% CI = 0.305-0.936; OR = 0.318, P = .029; OR = 0.318,95% CI = 0.173-0.586; P < .001) by Boston naming and animal fluency tests than did those with both sensorial and mobility frailty or mobility frailty only. Depressive symptoms had a significant negative influence on executive function. Cardiovascular disease and non-skin malignancy were independent determinants of MCI, and diabetes mellitus was independently associated with processing speed, attention, and executive function. Sensorial and mobility frailty were independent risk factors for cognitive impairment. Mobility frailty had a greater negative influence on the overall cognitive function and memory and language function than did sensorial frailty. The reserve decline in the psychological dimension of IC and chronic diseases also had a significant adverse influence on overall and domain-specific cognition function.
这项研究旨在探讨感觉和移动性虚弱对整体和特定领域认知功能的不同影响。此外，还研究了其他复杂能力（IC）维度，包括活力和心理维度，与整体和特定领域认知功能之间的独立关联。共有 429 名参与者（平均年龄 72.91±7.014 岁；57.30%为女性）接受了 IC 能力评估。还评估了其他协变量，如人口统计学、与健康相关的变量。在调整人口统计学、与健康相关和心理社会混杂因素后，将整体或特定领域认知障碍作为逻辑回归分析的因变量。调整人口统计学、与健康相关和心理社会混杂因素后，感觉虚弱的个体（优势比[OR] = 0.435；95%置信区间[CI] = 0.236-0.801；P = 0.008）发生轻度认知障碍（MCI）的风险显著降低，边缘记忆力障碍（OR = 0.601，95%CI = 0.347-1.040；P = 0.069）和语言障碍（OR = 0.534，95%CI = 0.305-0.936；OR = 0.318，P = 0.029；OR = 0.318，95%CI = 0.173-0.586；P<0.001）的风险降低，通过波士顿命名和动物流畅性测试。与仅感觉虚弱或感觉和移动性虚弱并存的个体相比，抑郁症状对执行功能有显著的负面影响。心血管疾病和非皮肤恶性肿瘤是 MCI 的独立决定因素，糖尿病与处理速度、注意力和执行功能独立相关。感觉和移动性虚弱是认知障碍的独立危险因素。与感觉虚弱相比，移动性虚弱对整体认知功能以及记忆和语言功能的负面影响更大。IC 心理维度和慢性疾病的储备下降也对整体和特定领域认知功能有显著的不利影响。
