[具有大汗腺分化和BRAF V600E突变的囊性小管乳头状腺瘤。病例报告及文献复习]
[Cystic tubulopapillary adenoma with apocrine differentiation and BRAF V600E mutation. A case report and review of the literature].
作者信息
Moreno Ontalba Alicia, Gómez Durán Áurea, Ruiz Cabezas Lismary, Cidoncha Pérez Esther, Díaz Delgado Mario, Rubio Fernández Alejandro
机构信息
Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Badajoz, Badajoz, España.
Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Badajoz, Badajoz, España.
出版信息
Rev Esp Patol. 2022 Sep;55 Suppl 1:S64-S68. doi: 10.1016/j.patol.2020.02.004. Epub 2020 Apr 18.
Syringocystadenoma papilliferum (SCAP), tubular adenoma (TA) and hydrocystoma (HC) are benign adnexal tumors. Recently it has been suggested that these lesions belong to the same morphological spectrum: Tubulopapillary cystic adenoma with apocrine differentiation (TPCAa). BRAF and K-Ras (KRAS) mutations have been described in SCAP and TA, but not in HC. Moreover, verrucous epithelial proliferations have been observed in TPCAa. We present a case of TPCAa with BRAF V600E mutation and BRAF VE1 immunohistochemical expression in the SCAP, AT, HC and verrucous hyperplasia components.
乳头状汗管囊腺瘤（SCAP）、管状腺瘤（TA）和汗腺囊瘤（HC）是良性附件肿瘤。最近有人提出，这些病变属于同一形态学谱系：具有大汗腺分化的管状乳头状囊腺瘤（TPCAa）。BRAF和K-Ras（KRAS）突变已在SCAP和TA中被描述，但在HC中未被描述。此外，在TPCAa中观察到疣状上皮增生。我们报告一例TPCAa病例，其在SCAP、AT、HC和疣状增生成分中存在BRAF V600E突变和BRAF VE1免疫组化表达。
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