Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Lugano, Switzerland; Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland.
Division of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.
Semin Nucl Med. 2023 Jan;53(1):78-85. doi: 10.1053/j.semnuclmed.2022.08.002. Epub 2022 Sep 6.
Currently, a large amount of evidence-based data clearly demonstrates the usefulness of [F]FDG PET/CT in the diagnosis of several infectious and inflammatory diseases, including those related to the large vessels. The aim of this article is to clarify whether, beyond initial diagnosis, [F]FDG PET/CT may have a role in treatment response assessment in inflammatory or infectious diseases of the large vessels, including large vessel vasculitis, vascular graft infection, retroperitoneal fibrosis/chronic periaortitis and infective native aortic aneurysms. Rapidly accumulating data suggest that [F]FDG PET/CT could be a valuable imaging method for therapy monitoring in some infectious and inflammatory diseases of large vessels. The available data, albeit preliminary, indicate that [F]FDG PET/CT could even play a pivotal role in the management of these diseases, leading to better drug dosage, confirmation of the usefulness of the treatment, and early modification of the therapeutic strategy. However, to date, the role of [F]FDG PET/CT for treatment assessment in large vessel diseases, in particular large vessel vasculitis, is not clearly defined and well-designed prospective studies are needed to confirm its possible role in treatment monitoring and treatment guidance.
目前，大量基于证据的数据清楚地表明 [F]FDG PET/CT 在诊断几种感染和炎症性疾病中的有用性，包括与大血管相关的疾病。本文的目的是阐明在初始诊断之外，[F]FDG PET/CT 是否可能在大血管的炎症或感染性疾病（包括大血管血管炎、血管移植物感染、腹膜后纤维化/慢性大动脉炎和感染性原生主动脉瘤）的治疗反应评估中发挥作用。越来越多的证据表明，[F]FDG PET/CT 可能是某些大血管感染和炎症性疾病治疗监测的一种有价值的影像学方法。虽然数据初步，但现有数据表明，[F]FDG PET/CT 甚至可能在这些疾病的治疗管理中发挥关键作用，从而更好地调整药物剂量、确认治疗的有效性，并早期调整治疗策略。然而，迄今为止，[F]FDG PET/CT 在大血管疾病（尤其是大血管血管炎）治疗评估中的作用尚未明确，需要进行精心设计的前瞻性研究来确认其在治疗监测和治疗指导中的可能作用。
