SARS-CoV-2 N7-甲基转移酶的高分辨率结构为治疗药物研发提供信息。
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
机构信息
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Nat Struct Mol Biol. 2022 Sep;29(9):850-853. doi: 10.1038/s41594-022-00828-1. Epub 2022 Sep 8.
Abstract
Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 Å), S-adenosylhomocysteine (1.55 Å) and sinefungin (1.41 Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.
摘要
SARS-CoV-2 冠状病毒的出现导致了数百万人的死亡。我们呈现了三个 SARS-CoV-2 nsp14 N7-甲基转移酶核心与 S-腺苷甲硫氨酸（1.62Å）、S-腺苷同型半胱氨酸（1.55Å）和 sinefungin（1.41Å）结合的高分辨率晶体结构。我们确定了甲基转移酶核心对于开发抗病毒药物至关重要的特征，并表明 SAH 是设计针对 SARS-CoV-2 和其他致病性冠状病毒的抗病毒药物的最佳支架。
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