Department of Anesthesiology, Suzukake Central Hospital, Hamamatsu, Japan.
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
J Anesth. 2022 Dec;36(6):688-692. doi: 10.1007/s00540-022-03093-0. Epub 2022 Sep 8.
This study was performed to examine and compare the incidence of extubation recall in surgical patients who underwent remimazolam anesthesia with flumazenil antagonism during emergence and in those who underwent propofol anesthesia.
One hundred sixty-three patients who underwent surgery using general endotracheal or supraglottic airway anesthesia with propofol (n = 97) or remimazolam (n = 66) were retrospectively analyzed. Remimazolam was antagonized by flumazenil after discontinuation of remimazolam at the end of surgery. The endotracheal tube or supraglottic airway was removed after surgery was complete, and consciousness and adequate spontaneous breathing were confirmed. The incidence of extubation recall was compared between the remimazolam and propofol anesthesia groups using propensity score matching.
Extubation recall was observed in 28 patients (17%). After propensity score matching, the incidence of extubation recall did not significantly differ between the remimazolam and propofol anesthesia groups (15.6% vs. 18.8%; p = 1.000).
The incidence of extubation recall after remimazolam anesthesia with flumazenil antagonism during emergence did not significantly differ from that after propofol anesthesia.
本研究旨在检查和比较在手术患者中，使用氟马西尼拮抗瑞马唑仑麻醉苏醒期和使用丙泊酚麻醉的患者中拔管回忆的发生率。
回顾性分析了 163 例使用全身气管内或声门上气道麻醉的手术患者，其中丙泊酚组（n=97）或瑞马唑仑组（n=66）。手术结束时停止使用瑞马唑仑后，用氟马西尼拮抗瑞马唑仑。手术完成后，拔出气管内导管或声门上气道，确认意识清醒和自主呼吸充足。使用倾向评分匹配比较瑞马唑仑和丙泊酚麻醉组之间拔管回忆的发生率。
28 例（17%）患者出现拔管回忆。经过倾向评分匹配后，瑞马唑仑和丙泊酚麻醉组之间拔管回忆的发生率无显著差异（15.6%比 18.8%；p=1.000）。
氟马西尼拮抗瑞马唑仑麻醉苏醒期的拔管回忆发生率与丙泊酚麻醉无显著差异。
