Dartmouth College, Department of Biological Sciences, Hanover, NH, USA.
Dartmouth College, Department of Biological Sciences, Hanover, NH, USA.
Neuron. 2022 Sep 7;110(17):2705-2707. doi: 10.1016/j.neuron.2022.08.002.
In this issue of Neuron, Imoto et al. report that a splice variant of dynamin (Dyn1xA) interacts with syndapin to form a molecular condensate at the edge of the presynaptic active zone. This enables rapid recruitment of proteins to endocytic sites essential for powering ultrafast endocytosis.
本期《神经元》杂志上,Imoto 等人报告称,一种拼接变体的动力蛋白(Dyn1xA)与衔接蛋白 Syndapin 相互作用,在突触前活性区的边缘形成一个分子凝聚物。这使得蛋白质能够快速募集到对于超快胞吞作用至关重要的内吞位点。