Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South Korea.
Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South Korea.
Biomed Pharmacother. 2022 Sep;153:113385. doi: 10.1016/j.biopha.2022.113385. Epub 2022 Jul 12.
Female menopause is a hormone deficiency phenomenon that causes hot flashes, vaginal dryness, depression, nervous tension, insomnia, obesity, and bone loss. There are various hormone replacement therapy (HRT)-based menopausal treatments, but they are accompanied by side effects such as endometrial cancer and hyperplasia. To confirm the menopausal improvement effect of Polygonatum sibiricum (PS), we prepared an ovariectomized animal model, administered 17β-estradiol (E2) and PS, and analyzed various menopausal symptoms. PS restored vaginal epithelium thickness, by increasing the expression of estrogen receptors ERα (ESR1) and ERβ (ESR2), and increased serotonin concentration by reducing serotonin receptor 1 A (5-HT1A) and glucocorticoid receptor (Gr) expression. In addition, PS suppressed obesity by increasing HDL-C and decreasing LDL-C levels and improved the osteoporosis induced by ovariectomy. In particular, by controlling Hand2, Fgf2, and Faf9 expression through PR, the antiproliferative signal was suppressed in uterine epithelium, thereby reducing the risk of side effects of the administration of E2 alone. These results demonstrate that PS alleviates menopausal symptoms without causing endometrial hyperplasia.
女性更年期是一种激素缺乏现象，会导致热潮红、阴道干燥、抑郁、神经紧张、失眠、肥胖和骨质流失。有各种基于激素替代疗法（HRT）的更年期治疗方法，但它们伴随着子宫内膜癌和增生等副作用。为了确认黄精（PS）对更年期的改善作用，我们制备了去卵巢动物模型，给予 17β-雌二醇（E2）和 PS，并分析了各种更年期症状。PS 通过增加雌激素受体 ERα（ESR1）和 ERβ（ESR2）的表达来恢复阴道上皮厚度，并通过降低 5-羟色胺受体 1A（5-HT1A）和糖皮质激素受体（Gr）的表达来增加 5-羟色胺浓度。此外，PS 通过增加 HDL-C 和降低 LDL-C 水平来抑制肥胖，并改善去卵巢引起的骨质疏松症。特别是，通过 PR 控制 Hand2、Fgf2 和 Faf9 的表达，抑制了子宫上皮的增殖信号，从而降低了单独使用 E2 给药的副作用风险。这些结果表明，PS 可缓解更年期症状而不会导致子宫内膜增生。
