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用于高效癌症诊断和治疗的靶向线粒体的治疗诊断纳米医学和分子生物标志物。

Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy.

机构信息

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi 221005, UP, India.

Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia; School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.

出版信息

Biomed Pharmacother. 2022 Sep;153:113451. doi: 10.1016/j.biopha.2022.113451. Epub 2022 Jul 26.

Abstract

Mitochondria play a crucial part in the cell's ability to adapt to the changing microenvironments and their dysfunction is associated with an extensive array of illnesses, including cancer. Mitochondrial dysfunction has been identified as a potential therapeutic target for cancer therapy. The objective of this article is to give an in-depth analysis of cancer treatment that targets the mitochondrial genome at the molecular level. Recent studies provide insights into nanomedicine techniques and theranostic nanomedicine for mitochondrial targeting. It also provides conceptual information on mitochondrial biomarkers for cancer treatment. Major drawbacks and challenges involved in mitochondrial targeting for advanced cancer therapy have also been discussed. There is a lot of evidence and reason to support using nanomedicine to focus on mitochondrial function. The development of a delivery system with increased selectivity and effectiveness is a prerequisite for a theranostic approach to cancer treatment. If given in large amounts, several new cancer-fighting medicines have been created that are toxic to healthy cells as well. For effective therapy, a new drug must be developed rather than an old one. When it comes to mitochondrial targeting therapy, theranostic techniques offer valuable insight.

摘要

线粒体在细胞适应不断变化的微环境的能力中起着至关重要的作用,其功能障碍与广泛的疾病有关,包括癌症。线粒体功能障碍已被确定为癌症治疗的潜在治疗靶点。本文的目的是深入分析在分子水平上靶向线粒体基因组的癌症治疗。最近的研究提供了对纳米医学技术和用于线粒体靶向的治疗诊断纳米医学的深入了解。它还为癌症治疗的线粒体生物标志物提供了概念信息。还讨论了用于晚期癌症治疗的线粒体靶向的主要缺点和挑战。有很多证据和理由支持使用纳米医学来关注线粒体功能。开发一种具有更高选择性和有效性的递药系统是癌症治疗治疗诊断方法的前提。如果大量给予,已经开发出几种对健康细胞也有毒性的新型抗癌药物。为了进行有效的治疗,必须开发新药而不是旧药。在涉及线粒体靶向治疗时,治疗诊断技术提供了有价值的见解。

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