Transfusion Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.
School of Medical and Life Sciences, Reproductive and Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Biomed Pharmacother. 2022 Sep;153:113519. doi: 10.1016/j.biopha.2022.113519. Epub 2022 Aug 16.
Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, is a matricellular protein involved in several biological processes including cell adhesion, growth factor availability, extracellular matrix remodeling and immune-regulation. SPARC has also been associated with a variety of diseases including diabetes, colon cancer, and leukemia. The expression of SPARC in different diseases exhibits some degree of ambiguity, especially in hemopathies. Herein, we review the current expression and effects of SPARC in various hematologic disorders with respect to nanoparticle albumin bound innovative therapies and related diagnostic research, providing a clinical perspective on the use of NAB technology in the frontier treatment of hematologic diseases.
富含半胱氨酸的酸性分泌蛋白（SPARC），也称为骨粘连蛋白或 BM-40，是一种细胞外基质蛋白，参与多种生物学过程，包括细胞黏附、生长因子的可用性、细胞外基质的重塑和免疫调节。SPARC 还与多种疾病有关，包括糖尿病、结肠癌和白血病。SPARC 在不同疾病中的表达表现出一定程度的不明确性，尤其是在血液疾病中。在此，我们回顾了 SPARC 在各种血液系统疾病中的表达和作用，涉及纳米颗粒白蛋白结合的创新疗法和相关诊断研究，为 NAB 技术在血液疾病前沿治疗中的应用提供了临床视角。
