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脑室内毛细胞型星形细胞瘤:单中心经验。

Intraventricular Pilocytic Astrocytoma: A Single Centre Experience.

机构信息

Department of Neurosurgery, AIIMS, New Delhi, India.

Department of Pathology, AIIMS, New Delhi, India.

出版信息

Neurol India. 2022 Jul-Aug;70(4):1468-1474. doi: 10.4103/0028-3886.355185.

Abstract

BACKGROUND

Intraventricular pilocytic astrocytomas are a rare occurrence, accounting for approximately 4% -15.6% of all pilocytic astrocytomas .The aim of the study was to describe the radiology, surgical management and outcome in 15 patients with histopathologically proven intraventricular pilocytic astrocytoma(IVPA).

OBJECTIVE

To study the clinical presentation radiology and operative challenges in rare intra ventricular pilocytic astrocytomas.

MATERIALS AND METHODS

Between January 2010 and August 2018, 15 patients with histopathologically proven IVPA were identified. The radiological images were obtained from PACS. Patient and surgical details were obtained from the computerized discharge summary, OT records and operative notes, whereas follow up was obtained from the record section.

RESULTS

Headache with progressive loss of vision was the most common presentation. Duration of symptoms varied from 4 months to 2 years (mean 9. 88 months). Except one patient, all patients with preoperative CT scan revealed calcifications in the lesion, with extensive calcification in 3 patients. All the tumors were predominantly hypointense on T1WI and iso to hyperintense on T2WI. Lesion in all patients showed heterogenous contrast enhancement on post gadolinium images. Mean blood loss in the series was 1969 ml (range 250 ml- 4500 ml).There was one death in this series due to meningitis and septic shock.

CONCLUSION

IVPAs are rare tumors and are difficult to diagnose in the preoperative period based on the radiologic profile alone. These tumors can be extremely vascular with potential for massive blood loss. These tumors can be associated with extensive calcification and the calcified tumors have less bleeding as expected.

摘要

背景

脑室内毛细胞型星形细胞瘤是一种罕见的病变,约占所有毛细胞型星形细胞瘤的 4%-15.6%。本研究旨在描述 15 例经组织病理学证实的脑室内毛细胞型星形细胞瘤(IVPA)患者的影像学、手术处理和结果。

目的

研究罕见的脑室内毛细胞型星形细胞瘤的临床表现、放射学特征和手术难点。

材料和方法

2010 年 1 月至 2018 年 8 月期间,共确诊 15 例 IVPA 患者。患者的影像学资料来自 PACS。患者的一般情况和手术相关细节信息可从住院病历、手术记录和手术记录中获得,而随访信息则来自病历记录。

结果

头痛伴进行性视力丧失是最常见的表现。症状持续时间从 4 个月到 2 年不等(平均 9.88 个月)。除了 1 例患者外,所有患者的术前 CT 扫描均显示病变有钙化,3 例患者有广泛钙化。所有肿瘤在 T1WI 上均呈低信号,在 T2WI 上呈等信号到高信号。所有患者的病灶在钆造影后均呈不均匀强化。本研究中平均失血量为 1969ml(范围 250ml-4500ml)。该系列中 1 例患者因脑膜炎和感染性休克而死亡。

结论

IVPA 是罕见的肿瘤,仅根据影像学特征很难在术前做出诊断。这些肿瘤可能具有高度血管化特征,存在大量出血的风险。这些肿瘤可能伴有广泛的钙化,而钙化的肿瘤的出血通常较少。

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