Department of Forensic Medicine, School of Basic Medicine and Biological Sciences, Soochow University, Suzhou 215123, China.
Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science), Shanghai 200063, China.
Int J Mol Sci. 2022 Aug 23;23(17):9519. doi: 10.3390/ijms23179519.
Neurological dysfunctions commonly occur after mild or moderate traumatic brain injury (TBI). Although most TBI patients recover from such a dysfunction in a short period of time, some present with persistent neurological deficits. Stress is a potential factor that is involved in recovery from neurological dysfunction after TBI. However, there has been limited research on the effects and mechanisms of stress on neurological dysfunctions due to TBI. In this review, we first investigate the effects of TBI and stress on neurological dysfunctions and different brain regions, such as the prefrontal cortex, hippocampus, amygdala, and hypothalamus. We then explore the neurobiological links and mechanisms between stress and TBI. Finally, we summarize the findings related to stress biomarkers and probe the possible diagnostic and therapeutic significance of stress combined with mild or moderate TBI.
神经功能障碍在轻度或中度创伤性脑损伤 (TBI) 后很常见。虽然大多数 TBI 患者在短时间内从这种功能障碍中恢复，但有些患者仍存在持续的神经缺陷。压力是 TBI 后神经功能障碍恢复过程中涉及的一个潜在因素。然而，由于 TBI，关于压力对神经功能障碍的影响和机制的研究有限。在这篇综述中，我们首先研究了 TBI 和压力对神经功能障碍和不同大脑区域的影响，如前额叶皮层、海马体、杏仁核和下丘脑。然后，我们探讨了压力和 TBI 之间的神经生物学联系和机制。最后，我们总结了与压力生物标志物相关的研究结果，并探讨了应激与轻度或中度 TBI 结合的可能诊断和治疗意义。
