Biomedical Research Centre (CINBIO), University of Vigo, Galicia Sur Health Research Institute, 36310 Vigo, Spain.
Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Int J Mol Sci. 2022 Aug 24;23(17):9583. doi: 10.3390/ijms23179583.
The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.
胰高血糖素样肽-1（GLP-1）是一种多功能激素，其在葡萄糖依赖性刺激胰岛素分泌方面的肠促胰岛素作用已广为人知。然而，GLP-1 也在大脑中产生，并通过激活 GLP-1 受体信号通路在神经保护和炎症中发挥关键作用。几项使用神经退行性疾病的临床前模型的体内和体外研究表明，GLP-1R 激活具有抗炎特性。本综述探讨了 GLP-1RAS 与大脑炎症相关的分子机制作用。这些发现更新了我们对 GLP-1RAS 作用降低炎症反应的潜在益处的认识。这些分子作为治疗神经退行性疾病和神经炎症性病理的潜在治疗工具出现。
