Pancancer Analysis of the Oncogenic and Prognostic Role of : A Potential Target for Carcinogenesis and Survival.

Despite growing evidence suggesting the critical function of in cancer initiation and development, a systematic pancancer analysis of is lacking. Herein, we present a comprehensive study of which aimed to explore its potential role and detailed mechanisms across 33 human tumors based on The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CATPAC) databases. As a result, both gene and protein levels of were found to be increased in various tumor tissues, including breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), and head and neck squamous cell carcinoma (HNSC) as compared with corresponding normal tissues. Meanwhile, dysregulated expression was found to be closely related to pathological stage and prognosis in several cancers, including LIHC, ovarian serous cystadenocarcinoma (OV), and bladder urothelial carcinoma (BLCA). The DNA methylation level of was found to be decreased in most cancers and to be negatively associated with expression. Furthermore, expression was determined to be significantly associated with levels of infiltrating cells and immune checkpoint genes, including . Analysis of -related genes revealed that RNA metabolism pathways, including "ribosome biogenesis", "spliceosome", and "RNA transport", were mainly involved in the functional mechanism of in human cancers. In summary, this pancancer study characterized the relationship between expression and clinicopathologic features in multiple cancer types and further showed its potential regulatory network in human cancers. It represents a systemic analysis for further functional and therapeutic studies of and highlights its predictive value with respect to the carcinogenesis and prognosis of various cancers, especially LIHC.