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壳聚糖-明胶薄膜用二醛纤维素纳米晶体交联作为潜在的伤口敷料材料。

Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings.

机构信息

Department of Biomedical Chemistry and Polymer Science, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland.

Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.

出版信息

Int J Mol Sci. 2022 Aug 26;23(17):9700. doi: 10.3390/ijms23179700.

DOI:10.3390/ijms23179700
PMID:36077096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9456065/
Abstract

In this study, thin chitosan-gelatin biofilms cross-linked with dialdehyde cellulose nanocrystals for dressing materials were received. Two types of dialdehyde cellulose nanocrystals from fiber (DNCL) and microcrystalline cellulose (DAMC) were obtained by periodate oxidation. An ATR-FTIR analysis confirmed the selective oxidation of cellulose nanocrystals with the creation of a carbonyl group at 1724 cm. A higher degree of cross-linking was obtained in chitosan-gelatin biofilms with DNCL than with DAMC. An increasing amount of added cross-linkers resulted in a decrease in the apparent density value. The chitosan-gelatin biofilms cross-linked with DNCL exhibited a higher value of roughness parameters and antioxidant activity compared with materials cross-linked with DAMC. The cross-linking process improved the oxygen permeability and anti-inflammatory properties of both measurement series. Two samples cross-linked with DNCL achieved an ideal water vapor transition rate for wound dressings, CS-Gel with 10% and 15% addition of DNCL-8.60 and 9.60 mg/cm/h, respectively. The swelling ability and interaction with human serum albumin (HSA) were improved for biofilms cross-linked with DAMC and DNCL. Significantly, the films cross-linked with DAMC were characterized by lower toxicity. These results confirmed that chitosan-gelatin biofilms cross-linked with DNCL and DAMC had improved properties for possible use in wound dressings.

摘要

在这项研究中，制备了交联有二醛纤维素纳米晶的壳聚糖-明胶薄型生物膜敷料材料。通过高碘酸盐氧化法获得了来源于纤维的两种二醛纤维素纳米晶（DNCL）和微晶纤维素（DAMC）。ATR-FTIR 分析证实了纤维素纳米晶的选择性氧化，在 1724 cm 处生成了羰基。与 DAMC 相比，DNCL 交联的壳聚糖-明胶生物膜具有更高的交联度。随着交联剂添加量的增加，表观密度值降低。与 DAMC 交联的材料相比，交联有 DNCL 的壳聚糖-明胶生物膜具有更高的粗糙度参数和抗氧化活性。交联过程改善了两种测试系列的氧气透过率和抗炎性能。两种交联有 DNCL 的样品实现了理想的伤口敷料水蒸气透过率，分别为 10%和 15%添加量的 CS-Gel 为 8.60 和 9.60 mg/cm/h。交联有 DAMC 和 DNCL 的生物膜的溶胀能力和与人血清白蛋白（HSA）的相互作用得到了改善。值得注意的是，交联有 DAMC 的薄膜的毒性较低。这些结果证实，交联有 DNCL 和 DAMC 的壳聚糖-明胶生物膜具有改善的性能，可能用于伤口敷料。

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