Yudaev Pavel, Tupikov Anton, Chistyakov Evgeniy
Chemical Technology of Russia, Mendeleev University, Miusskaya Sq. 9, 125047 Moscow, Russia.
Biomolecules. 2025 Feb 11;15(2):262. doi: 10.3390/biom15020262.
This review examines representatives of organocyclophosphazenes that can act against tumor cells of the ovaries, prostate gland, mammary gland, and colon, etc., and have antimicrobial action against mycobacteria , Gram-positive bacteria , Gram-negative bacteria , fungi of the genus , and other microorganisms. Cyclomatric phosphazenes can be used as carriers of physiologically active substances and in the field of detection, as well as gels for wound surgery and drug delivery platforms. In gels, cyclophosphazenes are used as cross-linking agents. Cyclophosphazenes containing multiple bonds in organic radicals are proposed to be used in dentistry as additives to basic dental compositions. Particular attention in the review is paid to the cytotoxic and antimicrobial action of materials containing cyclophosphazenes and their advantages over commercial physiologically active substances. The review presents the prospects for the practical application of cyclophosphazenes containing various functional groups (chalcone, anthraquinone, pyrrolidine, morpholine, and ferrocene, etc.) in pharmaceuticals. The review may be of interest to researchers working in the field of organoelement chemistry, medicine, and pharmacy.
本综述考察了有机环磷腈的代表物，它们可作用于卵巢、前列腺、乳腺和结肠等的肿瘤细胞，并对分枝杆菌、革兰氏阳性菌、革兰氏阴性菌、该属真菌及其他微生物具有抗菌作用。环三聚磷腈可用作生理活性物质的载体，并应用于检测领域，以及用于伤口手术的凝胶和药物递送平台。在凝胶中，环磷腈用作交联剂。含有有机基团中多重键的环磷腈被提议用作牙科基础组合物的添加剂。本综述特别关注含环磷腈材料的细胞毒性和抗菌作用及其相对于商业生理活性物质的优势。该综述展示了含有各种官能团（查尔酮、蒽醌、吡咯烷、吗啉和二茂铁等）的环磷腈在药物中的实际应用前景。本综述可能会引起从事有机元素化学、医学和药学领域研究的人员的兴趣。
