Association between Genotype with Body Composition and Cardiovascular Disease Risk Markers Is Modulated by BMI in Healthy Adults: Findings from the BODYCON Study.

Body mass index (BMI) has been suggested to play an important role in the relationship between the ( genotype and cardiovascular disease (CVD) risk. Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the association between body composition and CVD risk markers according to genotype, with examination of the role of BMI. In this study cohort, the group had lower fasting blood lipids than carriers and group ( ≤ 0.01). After stratifying the group according to BMI, carriers in the normal BMI subgroup had a higher lean mass compared with the group ( = 0.02) whereas in the overweight/obese subgroup, the android to gynoid percentage fat ratio was lower in carriers than group ( = 0.04). Fasting lipid concentrations were only different between the and other genotype groups within the normal weight BMI subgroup ( ≤ 0.04). This finding was associated with a lower dietary fibre and a higher trans-fat intake compared with carriers, and a lower carbohydrate intake relative to the group. Our results confirm previous reports that BMI modulates the effect of on CVD risk markers and suggest novel interactions on body composition, with diet a potential modulator of this relationship.