Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK.
Int J Mol Sci. 2022 Aug 29;23(17):9766. doi: 10.3390/ijms23179766.
Body mass index (BMI) has been suggested to play an important role in the relationship between the ( genotype and cardiovascular disease (CVD) risk. Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the association between body composition and CVD risk markers according to genotype, with examination of the role of BMI. In this study cohort, the group had lower fasting blood lipids than carriers and group ( ≤ 0.01). After stratifying the group according to BMI, carriers in the normal BMI subgroup had a higher lean mass compared with the group ( = 0.02) whereas in the overweight/obese subgroup, the android to gynoid percentage fat ratio was lower in carriers than group ( = 0.04). Fasting lipid concentrations were only different between the and other genotype groups within the normal weight BMI subgroup ( ≤ 0.04). This finding was associated with a lower dietary fibre and a higher trans-fat intake compared with carriers, and a lower carbohydrate intake relative to the group. Our results confirm previous reports that BMI modulates the effect of on CVD risk markers and suggest novel interactions on body composition, with diet a potential modulator of this relationship.
体重指数（BMI）被认为在 （基因型与心血管疾病（CVD）风险之间的关系中起着重要作用。利用来自 BODYCON 横断面研究的数据（n=360 名成年人），我们根据 基因型评估了身体成分与 CVD 风险标志物之间的关联，并考察了 BMI 的作用。在本研究队列中，与 携带者和 组相比， 组的空腹血脂较低（≤0.01）。根据 BMI 对 组进行分层后，正常 BMI 亚组中的 携带者与 组相比，瘦体重更高（=0.02），而在超重/肥胖亚组中，与 组相比， 携带者的男性到女性脂肪比例较低（=0.04）。只有在正常体重 BMI 亚组中，空腹血脂浓度在 与其他基因型组之间存在差异（≤0.04）。与 携带者相比，这一发现与膳食纤维摄入量较低、反式脂肪摄入量较高以及与 组相比碳水化合物摄入量较低有关。我们的研究结果证实了先前的报告，即 BMI 调节了 对 CVD 风险标志物的影响，并提示了身体成分的新的相互作用，饮食可能是这种关系的调节剂。
