Laboratories of Neuroimmunology, Service of Neurology and Neuroscience Research Center, Department of Clinical Neurosciences, Lausanne University Hospital, University of Lausanne, 1066 Lausanne, Switzerland.
Int J Mol Sci. 2022 Sep 4;23(17):10128. doi: 10.3390/ijms231710128.
Microbiota-derived metabolites are important molecules connecting the gut to the brain. Over the last decade, several studies have highlighted the importance of gut-derived metabolites in the development of multiple sclerosis (MS). Indeed, microbiota-derived metabolites modulate the immune system and affect demyelination. Here, we discuss the current knowledge about microbiota-derived metabolites implications in MS and in different mouse models of neuroinflammation. We focus on the main families of microbial metabolites that play a role during neuroinflammation. A better understanding of the role of those metabolites may lead to new therapeutical avenues to treat neuroinflammatory diseases targeting the gut-brain axis.
微生物衍生代谢物是连接肠道和大脑的重要分子。在过去的十年中，多项研究强调了肠道衍生代谢物在多发性硬化症 (MS) 发展中的重要性。事实上，微生物衍生代谢物调节免疫系统并影响脱髓鞘。在这里，我们讨论了有关微生物衍生代谢物在 MS 以及不同神经炎症小鼠模型中的作用的现有知识。我们专注于在神经炎症期间起作用的主要微生物代谢物家族。更好地了解这些代谢物的作用可能会为针对肠道-大脑轴的神经炎症性疾病开辟新的治疗途径。
