• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

三氟拉罗他定通过 IgE 和 IL-33 介导的 TAK1 和 MK2 的双重抑制抑制过敏炎症。

Trifuhalol A Suppresses Allergic Inflammation through Dual Inhibition of TAK1 and MK2 Mediated by IgE and IL-33.

机构信息

Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea.

Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Korea.

出版信息

Int J Mol Sci. 2022 Sep 5;23(17):10163. doi: 10.3390/ijms231710163.

DOI:10.3390/ijms231710163
PMID:36077570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9456157/
Abstract

The activation and degranulation of immune cells play a pivotal role in allergic inflammation, a pathological condition that includes anaphylaxis, pruritus, and allergic march-related diseases. In this study, trifuhalol A, a phlorotannin isolated from , inhibited the degranulation of immune cells and the biosynthesis of IL-33 and IgE in differentiated B cells and keratinocytes, respectively. Additionally, trifuhalol A suppressed the IL-33 and IgE-mediated activation of RBL-2H3 cells through the regulation of the TAK1 and MK2 pathways. Hence, the effect of trifuhalol A on allergic inflammation was evaluated using a Compound 48/80-induced systemic anaphylaxis mouse model and a house dust mite (HDM)-induced atopic dermatitis (AD) mouse model. Trifuhalol A alleviated anaphylactic death and pruritus, which appeared as an early-phase reaction to allergic inflammation in the Compound 48/80-induced systemic anaphylaxis model. In addition, trifuhalol A improved symptoms such as itching, edema, erythema, and hyperkeratinization in HDM-induced AD mice as a late-phase reaction. Moreover, the expression of IL-33 and thymic stromal lymphopoietin, inflammatory cytokines secreted from activated keratinocytes, was significantly reduced by trifuhalol A administration, resulting in the reduced infiltration of immune cells into the skin and a reduction in the blood levels of IgE and IL-4. In summarizing the above results, these results confirm that trifuhalol A is a potential therapeutic candidate for the regulation of allergic inflammation.

摘要

免疫细胞的激活和脱颗粒在过敏炎症中起着关键作用，过敏炎症是一种包括过敏反应、瘙痒和过敏进行曲相关疾病的病理状态。在这项研究中，三氟醇 A 是一种从分离得到的岩藻黄质，分别抑制了免疫细胞的脱颗粒和分化 B 细胞和角质形成细胞中白细胞介素 33 和 IgE 的生物合成。此外，三氟醇 A 通过调节 TAK1 和 MK2 途径抑制了白细胞介素 33 和 IgE 介导的 RBL-2H3 细胞的激活。因此，使用化合物 48/80 诱导的全身性过敏反应小鼠模型和屋尘螨 (HDM) 诱导的特应性皮炎 (AD) 小鼠模型评估了三氟醇 A 对过敏炎症的作用。三氟醇 A 减轻了过敏反应中早期反应的过敏反应引起的全身性过敏反应模型中的过敏死亡和瘙痒。此外，三氟醇 A 改善了 HDM 诱导的 AD 小鼠的瘙痒、水肿、红斑和过度角化等症状，这是过敏反应的晚期反应。此外，三氟醇 A 给药可显著降低活化角质形成细胞分泌的白细胞介素 33 和胸腺基质淋巴细胞生成素等炎症细胞因子的表达，从而减少免疫细胞浸润皮肤和降低血液中 IgE 和 IL-4 的水平。总之，这些结果证实三氟醇 A 是一种调节过敏炎症的潜在治疗候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/018c951adaf1/ijms-23-10163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/ca679686b100/ijms-23-10163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/3f53595f32b5/ijms-23-10163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/64af54f62781/ijms-23-10163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/17aca319bcbb/ijms-23-10163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/018c951adaf1/ijms-23-10163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/ca679686b100/ijms-23-10163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/3f53595f32b5/ijms-23-10163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/64af54f62781/ijms-23-10163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/17aca319bcbb/ijms-23-10163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85c/9456157/018c951adaf1/ijms-23-10163-g005.jpg

相似文献

1
Trifuhalol A Suppresses Allergic Inflammation through Dual Inhibition of TAK1 and MK2 Mediated by IgE and IL-33.三氟拉罗他定通过 IgE 和 IL-33 介导的 TAK1 和 MK2 的双重抑制抑制过敏炎症。
Int J Mol Sci. 2022 Sep 5;23(17):10163. doi: 10.3390/ijms231710163.
2
Anti-Allergic Inflammatory Effect of and Its Phlorotannin Component, Trifuhalol A, against the Ovalbumin-Induced Allergic Asthma Model.及其间苯三酚单宁成分三氟卤醇A对卵清蛋白诱导的过敏性哮喘模型的抗过敏炎症作用。
Curr Issues Mol Biol. 2023 Nov 5;45(11):8882-8893. doi: 10.3390/cimb45110557.
3
The interleukin-33 receptor ST2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma.白细胞介素-33受体ST2在哮喘的屋尘螨小鼠模型中，对于外周气道高反应性和炎症的发展至关重要。
Clin Exp Allergy. 2016 Mar;46(3):479-90. doi: 10.1111/cea.12683.
4
2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway.2-羟基-3-甲氧基苯甲酸通过调节FcεRI信号通路减轻小鼠肥大细胞介导的过敏反应。
Acta Pharmacol Sin. 2017 Jan;38(1):90-99. doi: 10.1038/aps.2016.112. Epub 2016 Nov 28.
5
Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions.芒柄花素抑制肥大细胞脱颗粒，改善 48/80 诱导的拟过敏反应。
Molecules. 2023 Jul 7;28(13):5271. doi: 10.3390/molecules28135271.
6
Lactococcus lactis KR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation.乳球菌 lactis KR-050L 提取物通过抑制角质形成细胞和肥大细胞的活化来抑制屋尘螨诱导的特应性皮炎炎症。
J Appl Microbiol. 2019 Jan;126(1):230-241. doi: 10.1111/jam.14116. Epub 2018 Oct 29.
7
Sopoongsan inhibits mast cell-mediated anaphylactic reactions and inflammatory cytokine secretion.索蓬山抑制肥大细胞介导的过敏反应和炎性细胞因子分泌。
Int Arch Allergy Immunol. 2006;139(1):31-7. doi: 10.1159/000089520. Epub 2005 Nov 3.
8
Xanthone suppresses allergic contact dermatitis in vitro and in vivo.黄烷酮在体外和体内抑制过敏性接触性皮炎。
Int Immunopharmacol. 2020 Jan;78:106061. doi: 10.1016/j.intimp.2019.106061. Epub 2019 Dec 9.
9
Rutin suppresses atopic dermatitis and allergic contact dermatitis.芦丁可抑制特应性皮炎和过敏性接触性皮炎。
Exp Biol Med (Maywood). 2013 Apr;238(4):410-7. doi: 10.1177/1535370213477975.
10
1,2,4,5-Tetramethoxybenzene Suppresses House Dust Mite-Induced Allergic Inflammation in BALB/c Mice.1,2,4,5-四甲氧基苯抑制屋尘螨诱导的BALB/c小鼠过敏性炎症。
Int Arch Allergy Immunol. 2016;170(1):35-45. doi: 10.1159/000446510. Epub 2016 Jun 30.

引用本文的文献

1
Trifuhalol A, a phlorotannin from the brown algae reduces adipogenesis of human primary adipocytes through Wnt/β-catenin and AMPK-dependent pathways.三氟卤醇A，一种来自褐藻的间苯三酚单宁，通过Wnt/β-连环蛋白和AMPK依赖途径减少人原代脂肪细胞的脂肪生成。
Curr Res Food Sci. 2023 Nov 22;7:100646. doi: 10.1016/j.crfs.2023.100646. eCollection 2023.
2
Anti-Allergic Inflammatory Effect of and Its Phlorotannin Component, Trifuhalol A, against the Ovalbumin-Induced Allergic Asthma Model.及其间苯三酚单宁成分三氟卤醇A对卵清蛋白诱导的过敏性哮喘模型的抗过敏炎症作用。
Curr Issues Mol Biol. 2023 Nov 5;45(11):8882-8893. doi: 10.3390/cimb45110557.
3

本文引用的文献

1
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.MYO1F 调节 IgE 和 MRGPRX2 依赖性肥大细胞脱颗粒。
J Immunol. 2021 May 15;206(10):2277-2289. doi: 10.4049/jimmunol.2001211. Epub 2021 May 3.
2
Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice.通过抑制白细胞介素-4在2,4-二硝基氯苯诱导的SKH-1无毛小鼠中提取改善的特应性皮炎样皮肤损伤。
Molecules. 2021 Apr 1;26(7):2016. doi: 10.3390/molecules26072016.
3
Scrophularia buergeriana attenuates allergic inflammation by reducing NF-κB activation.
Anti-Atopic Dermatitis Activity of -Oxyzoanthamine Isolated from Zoanthid.
从珊瑚虫中分离得到的-Oxyzoanthamine 具有抗特应性皮炎活性。
Mar Drugs. 2023 Aug 12;21(8):447. doi: 10.3390/md21080447.
玄参通过抑制 NF-κB 的激活减轻过敏炎症。
Phytomedicine. 2020 Feb;67:153159. doi: 10.1016/j.phymed.2019.153159. Epub 2019 Dec 24.
4
Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.白藜芦醇通过靶向 MK2/3-PI3K/Akt 轴抑制 IL-33 介导的肥大细胞活化。
Sci Rep. 2019 Dec 5;9(1):18423. doi: 10.1038/s41598-019-54878-5.
5
Topical Spilanthol Inhibits MAPK Signaling and Ameliorates Allergic Inflammation in DNCB-Induced Atopic Dermatitis in Mice.局部应用斯皮兰醇抑制 MAPK 信号通路并改善 DNCB 诱导的小鼠特应性皮炎的过敏炎症。
Int J Mol Sci. 2019 May 20;20(10):2490. doi: 10.3390/ijms20102490.
6
IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells-Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming.IL-33 和 MRGPRX2 触发人皮肤肥大细胞的激活-慢性暴露时消除受体表达，但急性引发时增强脱粒。
Cells. 2019 Apr 11;8(4):341. doi: 10.3390/cells8040341.
7
IL33: Roles in Allergic Inflammation and Therapeutic Perspectives.IL33：变应性炎症中的作用及治疗展望。
Front Immunol. 2019 Mar 4;10:364. doi: 10.3389/fimmu.2019.00364. eCollection 2019.
8
Optimization of Phlorotannins Extraction from and Evaluation of Their Potential to Prevent Metabolic Disorders.优化海葡萄中岩藻黄质的提取及其预防代谢紊乱的潜力评价。
Mar Drugs. 2019 Mar 8;17(3):162. doi: 10.3390/md17030162.
9
Emerging concepts: mast cell involvement in allergic diseases.新出现的概念：肥大细胞与过敏性疾病的关系
Transl Res. 2016 Aug;174:98-121. doi: 10.1016/j.trsl.2016.02.011. Epub 2016 Feb 24.
10
Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production.通过抑制胸腺基质淋巴细胞生成素的产生，二 Eckol 的局部应用改善了 NC/Nga 小鼠的特应性皮炎。
J Invest Dermatol. 2016 May;136(5):1062-1066. doi: 10.1016/j.jid.2015.12.046. Epub 2016 Mar 5.