Wach Johannes, Güresir Ági, Vatter Hartmut, Herrlinger Ulrich, Becker Albert, Toma Marieta, Hölzel Michael, Güresir Erdem
Department of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, 53127 Bonn, Germany.
Cancers (Basel). 2022 Sep 1;14(17):4285. doi: 10.3390/cancers14174285.
MIB-1 index is an important predictor of meningioma progression and was found to be correlated with COX-2 expression. However, the impact of low-dose acetylsalicylic acid (ASA) on MIB-1 index and clinical symptoms is unclear. Between 2009 and 2022, 710 patients with clinical data, tumor-imaging data, inflammatory laboratory (plasma fibrinogen, serum C-reactive protein) data, and neuropathological reports underwent surgery for primary cranial WHO grade 1 and 2 meningioma. ASA intake was found to be significantly associated with a low MIB-1 labeling index in female patients ≥ 60 years. Multivariable analysis demonstrated that female patients ≥ 60 years with a non-skull-base meningioma taking ASA had a significantly lower MIB-1 index (OR: 2.6, 95%: 1.0-6.6, = 0.04). Furthermore, the intake of ASA was independently associated with a reduced burden of symptomatic epilepsy at presentation in non-skull-base meningiomas in both genders (OR: 3.8, 95%CI: 1.3-10.6, = 0.03). ASA intake might have an anti-proliferative effect in the subgroup of elderly female patients with non-skull-base meningiomas. Furthermore, anti-inflammatory therapy seems to reduce the burden of symptomatic epilepsy in non-skull-base meningiomas. Further research is needed to investigate the role of anti-inflammatory therapy in non-skull-base meningiomas.
MIB-1指数是脑膜瘤进展的重要预测指标，且发现其与COX-2表达相关。然而，低剂量阿司匹林（ASA）对MIB-1指数和临床症状的影响尚不清楚。在2009年至2022年期间，710例有临床数据、肿瘤影像数据、炎症实验室（血浆纤维蛋白原、血清C反应蛋白）数据及神经病理学报告的患者接受了原发性世界卫生组织1级和2级颅底脑膜瘤手术。结果发现，≥60岁女性患者服用ASA与低MIB-1标记指数显著相关。多变量分析表明，≥60岁的非颅底脑膜瘤女性患者服用ASA后MIB-1指数显著降低（比值比：2.6，95%：1.0 - 6.6，P = 0.04）。此外，服用ASA与两性非颅底脑膜瘤患者出现症状性癫痫时的负担减轻独立相关（比值比：3.8，95%置信区间：1.3 - 10.6，P = 0.03）。服用ASA可能对老年非颅底脑膜瘤女性患者亚组具有抗增殖作用。此外，抗炎治疗似乎可减轻非颅底脑膜瘤患者症状性癫痫的负担。需要进一步研究来探讨抗炎治疗在非颅底脑膜瘤中的作用。
