Iordache Miorita Melina, Tocia Cristina, Aschie Mariana, Dumitru Andrei, Manea Mihaela, Cozaru Georgeta Camelia, Petcu Lucian, Vlad Sabina E, Dumitru Eugen, Chisoi Anca
Faculty of Medicine, Ovidius University of Constanta, 1 Universitatii Alley, 900470 Constanta, Romania.
Prof. Alexandru Obregia Psychiatry Hospital, 10 Berceni Str., 041914 Bucharest, Romania.
J Clin Med. 2022 Aug 30;11(17):5121. doi: 10.3390/jcm11175121.
Depression is a global health problem that requires an early and accurate diagnosis to ensure quick access to appropriate treatment. Among multiple psychopathological paths, recent attention has focused on analysing the brain-gut-microbiota axis. The intestinal barrier plays a key role, and dysfunctions occurring at this level have implications for mental health. The aim of the present study was to investigate the role of intestinal permeability biomarkers, i.e., calprotectin, zonulin, lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FAB), in relation to depression in patients with inflammatory bowel disease (IBD). This is the first study of this kind taking place in Romania, Eastern Europe, with an emphasis on patients with Crohn's disease and ulcerative colitis. The correlations identified between depression and calprotectin and depression and LBP have the potential to shed light on the process of rapid diagnosis of depression with the help of biomarkers. Since depression is correlated with a decrease in the quality of life in patients with IBD, the need for access to appropriate treatments must be urgent.
抑郁症是一个全球性的健康问题，需要早期准确诊断以确保能迅速获得适当治疗。在多种精神病理学途径中，近期的注意力集中在分析脑-肠-微生物群轴。肠道屏障起着关键作用，在此水平发生的功能障碍对心理健康有影响。本研究的目的是调查肠道通透性生物标志物，即钙卫蛋白、闭合蛋白、脂多糖结合蛋白（LBP）和肠脂肪酸结合蛋白（I-FAB）在炎症性肠病（IBD）患者抑郁症中的作用。这是在东欧罗马尼亚进行的此类首次研究，重点关注克罗恩病和溃疡性结肠炎患者。抑郁症与钙卫蛋白以及抑郁症与LBP之间确定的相关性有可能借助生物标志物为抑郁症的快速诊断过程提供线索。由于抑郁症与IBD患者生活质量下降相关，迫切需要获得适当治疗。
