Miñambres Inka, Sardà Helena, Urgell Eulalia, Genua Idoia, Ramos Analía, Fernández-Ananin Sonia, Balagué Carmen, Sánchez-Quesada Jose Luis, Bassas Lluís, Pérez Antonio
Endocrinology and Nutrition Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Medicine Department, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.
J Clin Med. 2022 Aug 31;11(17):5126. doi: 10.3390/jcm11175126.
(1) Background: Obesity is associated with hypogonadism, sexual dysfunction, and impaired fertility in men. However, its effects on semen parameters or sexual function remain debatable. (2) Methods: This paper involves a longitudinal study in men submitted for obesity surgery at a university tertiary hospital. Patients were studied at baseline and at 6, 12, and 18 months after obesity surgery. At each visit, anthropometry measures were collected and hormonal and semen parameters were studied. Sexual function was evaluated with the International Index of Erectile Function (IIEF). (3) Results: A total of 12 patients were included. The average body mass index of patients decreased from 42.37 ± 4.44 to 29.6 ± 3.77 kg/m2 at 18 months after surgery (p < 0.05). Hormonal parameters improved after obesity surgery. The proportion of sperm cells with normal morphology tended to decrease from baseline and became most significant at 18 months (5.83 ± 4.50 vs. 2.82 ± 2.08). No significant changes were found in the remaining semen parameters. Erectile function improved significantly at six months after surgery. (4) Conclusions: The authors believe that, in general, the effects of obesity surgery on fertility may be limited or even deleterious (at least in the short and midterm follow-up).
(1) 背景：肥胖与男性性腺功能减退、性功能障碍及生育能力受损有关。然而，其对精液参数或性功能的影响仍存在争议。(2) 方法：本文涉及一项对在大学三级医院接受肥胖手术的男性进行的纵向研究。在基线以及肥胖手术后6个月、12个月和18个月对患者进行研究。每次就诊时，收集人体测量数据并研究激素和精液参数。使用国际勃起功能指数（IIEF）评估性功能。(3) 结果：共纳入12例患者。术后18个月时患者的平均体重指数从42.37±4.44降至29.6±3.77kg/m²（p<0.05）。肥胖手术后激素参数有所改善。形态正常的精子细胞比例从基线开始趋于下降，在18个月时最为显著（5.83±4.50对2.82±2.08）。其余精液参数未发现显著变化。术后6个月勃起功能显著改善。(4) 结论：作者认为，总体而言，肥胖手术对生育能力可能有限制作用，甚至可能有害（至少在短期和中期随访中）。
