Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan-si 31151, Korea.
Department of Surgery, Inje University, Ilsan Paik Hospital, Goyang-si 10380, Korea.
Nutrients. 2022 Aug 24;14(17):3461. doi: 10.3390/nu14173461.
This study investigated the effects of folic acid on obesity and high-sensitivity C-reactive protein (CRP) levels. Using data from the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016-2018), 6394 adults (aged 19-80 years) who met the study criteria were identified and divided into young, middle-aged, and older adult groups. The analysis assessed associations using logistic regression for complex samples. Obesity was measured using body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI). The odds ratio (OR) of obesity based on BMI were statistically significant for young adults and older participants with low levels of folic acid compared to those with high levels (OR: 1.33 and 1.58, respectively). The OR of obesity based on BMI, WC, WHtR, ABSI, and BRI was significant with low levels of folic acid in middle-aged individuals (OR: 1.36, 1.32, 1.41, 1.29, and 1.47, respectively). Low folate levels were related to higher high-sensitivity CRP levels in middle-aged patients. In conclusion, folate level showed a significant inverse association with obesity and inflammatory biomarkers, especially in the middle-aged group. Further longitudinal or randomized controlled trials are needed to confirm and expand our results.
本研究探讨了叶酸对肥胖和高敏 C 反应蛋白（CRP）水平的影响。使用来自韩国国家健康和营养检查调查（KNHANES VII 2016-2018）的数据，确定了 6394 名符合研究标准的成年人（年龄在 19-80 岁之间），并将其分为青年、中年和老年组。使用复杂样本的逻辑回归评估了关联。肥胖使用体重指数（BMI）、腰围（WC）、腰高比（WHtR）、身体形状指数（ABSI）和身体圆润度指数（BRI）来衡量。与高水平叶酸相比，年轻和老年参与者中叶酸水平低的肥胖几率（OR：1.33 和 1.58）在 BMI 方面具有统计学意义。BMI、WC、WHtR、ABSI 和 BRI 方面的肥胖几率在中年个体中叶酸水平低的情况下具有显著意义（OR：1.36、1.32、1.41、1.29 和 1.47）。叶酸水平低与中年患者的高敏 CRP 水平升高有关。总之，叶酸水平与肥胖和炎症生物标志物呈显著负相关，尤其是在中年组。需要进一步的纵向或随机对照试验来证实和扩展我们的结果。
