Food & Health Lab, Institute of Materials Science, University of Valencia, 46980 Valencia, Spain.
Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, 46026 Valencia, Spain.
Nutrients. 2022 Aug 30;14(17):3575. doi: 10.3390/nu14173575.
Nowadays, slimming diet methodology works within a reduction of body mass using a decrease of dietary energy intake. However, there is no suitable method for understanding the dynamic process of body mass metabolic transformation over time. In the present paper, we have developed a biomathematic model to explain the temporal trend of body mass and its variations of people who have undergone a change in their diet using the solving equation of the model. Data relating to sex, age, body mass, and BMI were collected, and the compartmental model used to interpret the body mass trends was constructed by assuming that the mass results from the sum of the metabolic processes: catabolic, anabolic, distributive. The validation of the model was carried out by variance analysis both on the total and individual data sets. The results confirm that the trend of body mass and its variations over time depends on metabolic rates. These are specific to each individual and characterize the distribution of nutritional molecules in the various body districts and the processes catabolic, anabolic, distributive. Body mass and its variations are justified by the metabolic transformations of the nutritional quantities. This would explain why energetically equal diets can correspond to people of different body mass and that energy-different diets can correspond to people of body mass at all similar.
如今,减肥饮食方法通过减少饮食能量摄入来控制体重。然而,目前还没有合适的方法来理解人体体重随时间变化的动态代谢转化过程。在本文中,我们开发了一个生物数学模型,通过求解模型方程来解释饮食改变后人体体重及其变化的时间趋势。收集了与性别、年龄、体重和 BMI 相关的数据,并通过假设质量是由代谢过程(分解代谢、合成代谢、分配)的总和产生的,构建了用于解释体重趋势的房室模型。通过对总数据集和单个数据集进行方差分析对模型进行了验证。结果证实,体重及其随时间变化的趋势取决于代谢率。这些代谢率是特定于个体的,它们描述了营养分子在各个身体部位的分布以及分解代谢、合成代谢、分配过程。体重及其变化是由营养物质的代谢转化来解释的。这就解释了为什么能量相等的饮食可以对应不同体重的人,而能量不同的饮食可以对应体重相似的所有人。