Clinical Nutrition Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125 Parma, Italy.
Nutrients. 2022 Aug 31;14(17):3609. doi: 10.3390/nu14173609.
It is unclear whether weight loss (WL) achieved by means of lifestyle interventions (LSIs) before bariatric surgery (BS) can improve long-term WL outcomes after surgery. We aimed to assess the impact of a structured LSI on WL% after gastric bypass (GBP). Two groups of patients were selected from a large cohort of participants with obesity who underwent GBP surgery at Santa Maria Nuova Hospital (Reggio Emilia, Italy). The groups were categorized as those who have or have not received LSI prior to GBP. The LSI group included 91 participants (cases) compared to 123 participants (controls) in the non-LSI group. WL% was measured at follow-up times of 1, 3, 6, 12, 24, 36, 48, and 60 months. The LSI group achieved a clinically significant WL% (-7.5%) before BS, and at the time of surgery, the two groups had similar body weights and demographic statuses. At all points, until the 24-month follow-up, the two groups displayed similar WLs%. With regard to the longer follow-ups, the LSI group maintained weight loss until the last timepoint (60 months), whereas the non-LSI group experienced weight regain at 36, 48, and 60 months. In a real-world context, a structured behavioral LSI prior to GBP seems to prevent longer-term weight regain.
尚不清楚减重手术（BS）前通过生活方式干预（LSI）实现的体重减轻是否能改善手术后的长期减重效果。我们旨在评估胃旁路术（GBP）前结构化 LSI 对减重百分比（WL%）的影响。从在意大利雷焦艾米利亚的圣玛丽亚诺瓦医院接受 GBP 手术的肥胖患者的大型队列中选择了两组患者。这些组被归类为是否在 GBP 前接受 LSI 的组。LSI 组包括 91 名参与者（病例），而非 LSI 组包括 123 名参与者（对照）。在 1、3、6、12、24、36、48 和 60 个月的随访时间测量 WL%。LSI 组在 BS 前实现了临床显著的 WL%（-7.5%），并且在手术时，两组的体重和人口统计学状况相似。在所有时间点，直到 24 个月的随访，两组的减重效果相似。对于更长的随访，LSI 组在最后一次随访时（60 个月）保持体重减轻，而非 LSI 组在 36、48 和 60 个月时出现体重反弹。在真实环境中，GBP 前进行结构化行为 LSI 似乎可以预防长期体重反弹。
